Multifunctional antioxidants for the treatment of age-related diseases.
Multifunctional antioxidants for the treatment of age-related diseases.
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DOI：
10.1021/jm901381j
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发表时间：
2010-02-11
影响因子：
7.3
通讯作者：
Kador, Peter F.
中科院分区：
文献类型：
--
作者：
Jin, Hongxia;Randazzo, James;Zhang, Peng;Kador, Peter F.
合成了具有自由基清除剂基团（FRS）、螯合基团（CHL）或两者（FRS+CHL）的N，N-二甲基-4-（嘧啶-2-基）-哌嗪-1-磺酰胺的类似物。电喷雾电离质谱研究表明，该系列的选择成员以Cu 1 += Cu 2 + > Fe 2 += Fe 3 +> Zn 2+的相对顺序结合离子，未观察到Ca 2+或Mg 2+的结合。这些化合物在人透镜上皮细胞、人视网膜色素上皮细胞和人海马星形胶质细胞系中的体外评价表明，所有具有FRS基团的类似物以及水溶性维生素E类似物6-羟基-2，5，7，8-四甲基苯并二氢吡喃-2-羧酸保护这些细胞免受过氧化氢诱导的细胞活力和谷胱甘肽水平降低。此外，那些具有CHL基团的化合物还保护这些细胞免受由芬顿反应产生的羟基自由基的侵害。这些化合物是预防性治疗白内障、年龄相关性黄斑变性（AMD）和阿尔茨海默氏痴呆（AD）的良好候选物。
Analogs of N,N-dimethyl-4-(pyrimidin-2-yl)- piperazine-1-sulfonamide possessing either a free radical scavenger group (FRS), chelating groups (CHL), or both (FRS+CHL) have been synthesized. Electrospray ionization mass spectrometry studies indicate that select members of this series bind ions in the relative order of Cu1+= Cu2+ > Fe2+= Fe3+>Zn2+ with no binding of Ca2+ or Mg2+ observed. In vitro evaluation of these compounds in human lens epithelial, human retinal pigmented epithelial, and human hippocampal astrocyte cell lines indicates that all analogs possessing the FRS group as well as the water soluble vitamin E analog 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid protect these cells against decreased cell viability and glutathione levels induced by hydrogen peroxide. In addition, those compounds possessing CHL groups also protected these cells against hydroxyl radicals generated by the Fenton reaction. These compounds are good candidates for the preventive treatment of cataract, age-related macular degeneration (AMD), and Alzheimer's dementia (AD).
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影响因子：
2.9
作者：
Cuajungco, MP;Lees, GJ
通讯作者：
Lees, GJ
DOI：
10.1046/j.1532-5415.2003.51368.x
发表时间：
2003-08-01
影响因子：
6.3
作者：
Finefrock, AE;Bush, AI;Doraiswamy, PM
通讯作者：
Doraiswamy, PM
DOI：
10.1080/10401230500296428
发表时间：
2005-10-01
期刊：
Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists
影响因子：
--
作者：
Frank, Bradford;Gupta, Sanjay
通讯作者：
Gupta, Sanjay
影响因子：
3.8
作者：
Garner, B;Roberg, K;Truscott, RJW
通讯作者：
Truscott, RJW
影响因子：
3.9
作者：
Allsop, David;Mayes, Jennifer;Tabner, Brian J.
通讯作者：
Tabner, Brian J.