Growth factor delivery strategies for rotator cuff repair and regeneration.
Growth factor delivery strategies for rotator cuff repair and regeneration.
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DOI：
10.1016/j.ijpharm.2018.01.006
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发表时间：
2018-06-15
影响因子：
5.8
通讯作者：
Laurencin CT
中科院分区：
文献类型：
--
作者：
Prabhath A;Vernekar VN;Sanchez E;Laurencin CT
手术修复后退行性撕裂的高发生率和再撕裂的患病率（20-95%）使肩袖损伤成为一个严重的健康问题。这种高再撕裂率是由于修复的组织无法再生天然肌腱-骨插入（附着点）。手术修复的生物增强，如自体移植物、同种异体移植物和异种移植物，分别受到供体部位发病率、免疫原性和疾病传播的混淆。相比之下，这些风险可以通过生长因子治疗来缓解，生长因子治疗可以积极影响愈合环境以促进功能修复。在生长因子递送可以转化为临床实践之前，必须克服几个挑战，例如选择最佳生长因子或组合，确定最有效的递送阶段和持续时间，以及递送装置的设计考虑。对损伤修复微环境的新见解和我们对愈合中生长因子机制的理解正在为先进的输送支架的设计提供信息，以有效治疗肩袖撕裂。在这里，我们审查潜在的生长因子候选人，设计参数和材料选择生长因子输送，创新和动态输送支架，和新的治疗目标，从肌腱和发育生物学的结构和功能愈合的肩袖修复。
The high incidence of degenerative tears and prevalence of retears (20–95%) after surgical repair makes rotator cuff injuries a significant health problem. This high retear rate is attributed to the failure of the repaired tissue to regenerate the native tendon-to-bone insertion (enthesis). Biological augmentation of surgical repair such as autografts, allografts, and xenografts are confounded by donor site morbidity, immunogenicity, and disease transmission, respectively. In contrast, these risks may be alleviated via growth factor therapy, which can actively influence the healing environment to promote functional repair. Several challenges have to be overcome before growth factor delivery can translate into clinical practice such as the selection of optimal growth factor(s) or combination, identification of the most efficient stage and duration of delivery, and the design considerations for the delivery device. Emerging insight into the injury-repair microenvironment and our understanding of growth factor mechanisms in healing are informing the design of advanced delivery scaffolds to effectively treat rotator cuff tears. Here, we review potential growth factor candidates, design parameters and material selection for growth factor delivery, innovative and dynamic delivery scaffolds, and novel therapeutic targets from tendon and developmental biology for the structural and functional healing of rotator cuff repair.
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影响因子：
2.8
作者：
Dahlgren, LA;Mohammed, HO;Nixon, AJ
通讯作者：
Nixon, AJ
影响因子：
7.3
作者：
Akasaka, Y;Ono, I;Ishii, T
通讯作者：
Ishii, T
影响因子：
4.8
作者：
Cushing, Melinda C.;Mariner, Peter D.;Liao, Jo-Tsu;Sims, Evan A.;Anseth, Kristi S.
通讯作者：
Anseth, Kristi S.
影响因子：
5.3
作者：
Derwin, Kathleen A.;Codsi, Michael J.;Iannotti, Joseph P.
通讯作者：
Iannotti, Joseph P.
DOI：
10.1097/bto.0000000000000168
发表时间：
2016-06
期刊：
Techniques in orthopaedics (Rockville, Md.)
影响因子：
--
作者：
Chainani A;Little D
通讯作者：
Little D