The expression of LC-3 is related to tumor suppression through angiogenesis in esophageal cancer.
The expression of LC-3 is related to tumor suppression through angiogenesis in esophageal cancer.
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DOI：
10.1007/s12032-013-0701-x
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Natsugoe S
中科院分区：
文献类型：
--
作者：
Sakurai T;Okumura H;Matsumoto M;Uchikado Y;Setoyama T;Omoto I;Owaki T;Maemura K;Ishigami S;Natsugoe S
自噬在细胞的发育和重塑中起着重要的作用。它是细胞适应营养剥夺和消除受损细胞器所必需的。近年来，自噬已被认为与肿瘤的发生和转移有关。我们假设自噬相关蛋白是在血管生成提供营养之前启动的。我们评估了LC3（一种自噬标志物）的临床病理意义及其与食管鳞状细胞癌（ESCC）患者血管生成的关系。我们用免疫组织化学方法研究了142例ESCC患者中LC3、内皮素（CD105）（微血管标志物）和血管内皮生长因子a （VEGF-A）的表达。LC3高、中、低表达率分别为40%、31%、29%。LC3表达与浸润深度、淋巴结转移、淋巴浸润、MVD、VEGF-A表达、预后不良呈负相关。LC3高表达患者的总生存率高于LC3低表达患者。我们证明低LC3表达与血管生成促进的肿瘤发展有关，LC3表达的改变与预后密切相关。LC3蛋白的表达是确定ESCC患者肿瘤预后行为的有用标志物。
Autophagy is important in the development and remodeling of cells. It is required for cellular adaptation to nutrient deprivation and elimination of damaged organelles. Recently, autophagy has been implicated in carcinogenesis and metastasis. We hypothesized that autophagy-related proteins are initiated until nutrition is supplied by angiogenesis. We evaluated the clinicopathological significance of LC3, an autophagic marker, and its relationship to angiogenesis in patients with esophageal squamous cell carcinoma (ESCC). We immunohistochemically investigated the expression of LC3 as well as endoglin (CD105), a microvessel marker, and vascular endothelial growth factor A (VEGF-A) in 142 patients with ESCC. The high, moderate, and low expression rates of LC3 were 40, 31, and 29 %. LC3 expression inversely correlated with depth of invasion, lymph node metastasis, lymphatic invasion, MVD, VEGF-A expression, and poor prognosis. The overall survival rate was better in patients with high LC3 expression compared to patients with low LC3 expression. We demonstrate that low LC3 expression is related to tumor development as facilitated by angiogenesis and that alteration in LC3 expression is closely related to prognosis. Expression of LC3 proteins is a useful marker for determining tumor prognostic behavior in patients with ESCC.
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DOI：
10.1016/j.biocel.2004.05.009
发表时间：
2004-12
期刊：
The international journal of biochemistry & cell biology
影响因子：
--
作者：
Tanida I;Ueno T;Kominami E
通讯作者：
Kominami E
影响因子：
3.8
作者：
Akagi, K;Ikeda, Y;Abe, T
通讯作者：
Abe, T
影响因子：
5.7
作者：
Fujii, Satoshi;Mitsunaga, Shuichi;Ochiai, Atsushi
通讯作者：
Ochiai, Atsushi
影响因子：
3.3
作者：
Mizushima, N;Yamamoto, A;Ohsumi, Y
通讯作者：
Ohsumi, Y
影响因子：
3.7
作者：
Logan-Collins, Jocelyn M.;Lowy, Andrew M.;Ahmad, Syed A.
通讯作者：
Ahmad, Syed A.