Crawling wounded: molecular genetic insights into wound healing from Drosophila larvae.
Crawling wounded: molecular genetic insights into wound healing from Drosophila larvae.
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DOI：
10.1387/ijdb.180085mg
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Galko MJ
中科院分区：
文献类型：
--
作者：
Tsai CR;Wang Y;Galko MJ
For animals, injury is inevitable. Because of this, organisms possess efficient wound healing mechanisms that can repair damaged tissues. However, the molecular and genetic mechanisms by which epidermal repair is accomplished remain poorly defined. Drosophila has become a valuable model to study epidermal wound healing because of the comprehensive genetic toolkit available in this organism and the similarities of wound healing processes between Drosophila and vertebrates. Other reviews in this Special Issue cover wound healing assays and pathways in Drosophila embryos, pupae and adults, as well as regenerative processes that occur in tissues such as imaginal discs and the gut. In this review, we will focus on the molecular/genetic control of wound-induced cellular processes such as inflammation, cell migration and epithelial cell-cell fusion in Drosophila larvae. We will give a brief overview of the three wounding assays, pinch, puncture, and laser ablation, and the cellular responses that ensue following wounding. We will highlight the actin regulators, signaling pathways and transcriptional mediators found so far to be involved in larval epidermal wound closure and what is known about how they act. We will also discuss wound-induced epidermal cell-cell fusion and possible directions for future research in this exciting system.
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影响因子：
17.1
作者：
Eming SA;Martin P;Tomic-Canic M
通讯作者：
Tomic-Canic M
影响因子：
1.2
作者：
Bach, Erika A.;Ekas, Laura A.;Baeg, Gyeong-Hun
通讯作者：
Baeg, Gyeong-Hun
影响因子：
2.6
作者：
Gangishetti, U.;Veerkamp, J.;Moussian, B.
通讯作者：
Moussian, B.
DOI：
10.1073/pnas.0709951105
发表时间：
2008-07-22
影响因子：
11.1
作者：
Babcock, Daniel T.;Brock, Amanda R.;Galko, Michael J.
通讯作者：
Galko, Michael J.
一种基于多功能φC31的记者系统，用于测量果蝇和组织培养中的AP-1和NRF2信号传导。
影响因子：
3.7
作者：
Chatterjee N;Bohmann D
通讯作者：
Bohmann D