Coronary heart disease in African Americans.
Coronary heart disease in African Americans.
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非裔美国人的冠心病。
DOI：
--
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
J. Wright
中科院分区：
文献类型：
--
作者：
L. Clark;K. Ferdinand;J. Flack;J. Gavin;W. Hall;S. Kumanyika;J. W. Reed;E. Saunders;H. Valantine;K. Watson;N. Wenger;J. Wright
非裔美国人的冠心病（CHD）总死亡率是美国任何种族群体中最高的，特别是医院外死亡，尤其是在年轻时。尽管非裔美国人冠心病死亡率过高的所有原因尚未阐明，但很明显，某些冠心病危险因素的患病率很高，对高危人群的识别和治疗延迟，以及心血管护理的获得有限。非裔美国人的急性和慢性CHD的临床谱与白人相似。然而，非裔美国人有更高的心脏性猝死的风险，更经常出现不稳定型心绞痛和非Q波心肌梗死比白人。非裔美国人的冠状动脉造影显示阻塞性冠状动脉疾病较少，但可能有相似或更大的冠状动脉粥样硬化总负担。冠心病临床表现的种族差异可能主要由冠状动脉综合征的固有异质性以及非裔美国人高血压和2型糖尿病的不成比例的高患病率和严重程度来解释。识别高危人群，积极改变危险因素，特别是控制高血压、左心室肥厚消退、控制糖尿病、治疗血脂异常和戒烟，是成功降低风险的关键。
African Americans have the highest overall mortality rate from coronary heart disease (CHD) of any ethnic group in the United States, particularly out-of-hospital deaths, and especially at younger ages. Although all of the reasons for the excess CHD mortality among African Americans have not been elucidated, it is clear that there is a high prevalence of certain coronary risk factors, delay in the recognition and treatment of high-risk individuals, and limited access to cardiovascular care. The clinical spectrum of acute and chronic CHD in African Americans is similar to that in whites. However, African Americans have a higher risk of sudden cardiac death and present more often with unstable angina and non-Q-wave myocardial infarction than whites. African Americans have less obstructive coronary artery disease on angiography, but may have a similar or greater total burden of coronary atherosclerosis. Ethnic differences in the clinical manifestations of CHD may be explained largely by the inherent heterogeneity of the coronary syndromes, and the disproportionately high prevalence and severity of hypertension and type 2 diabetes in African Americans. Identification of high-risk individuals for vigorous risk factor modification-especially control of hypertension, regression of left ventricular hypertrophy, control of diabetes, treatment of dyslipidemia, and smoking cessation--is key for successful risk reduction.
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影响因子：
120.7
作者：
Stone, PH;Thompson, B;Braunwald, E
通讯作者：
Braunwald, E
影响因子：
5.6
作者：
N. Traven;Lewis H. Kuller;Diane G. Ives;G. Rutan;J. Perper;J. Perper
通讯作者：
N. Traven;Lewis H. Kuller;Diane G. Ives;G. Rutan;J. Perper;J. Perper
影响因子：
158.5
作者：
KEIL, JE;SUTHERLAND, SE;TYROLER, HA
通讯作者：
TYROLER, HA
影响因子：
37.8
作者：
Folsom, AR;Wu, KK;Chambless, LE
通讯作者：
Chambless, LE
影响因子：
4.8
作者：
Gillum,RF;Grant,CT
通讯作者：
Grant,CT