The neural distribution of the avian homologue of oxytocin, mesotocin, in two songbird species, the zebra finch and the canary: A potential role in song perception and production.
The neural distribution of the avian homologue of oxytocin, mesotocin, in two songbird species, the zebra finch and the canary: A potential role in song perception and production.
复制标题
DOI：
10.1002/cne.25338
复制
发表时间：
2022-09
影响因子：
2.5
通讯作者：
Ball, Gregory F.
中科院分区：
文献类型：
--
作者：
Haakenson, Chelsea M.;Balthazart, Jacques;Madison, Farrah N.;Ball, Gregory F.
催产素（OT）的鸟类同系物，以前称为中产素，影响鸣禽的社会行为和潜在的歌曲产生。我们试图表征 OT 肽在两种鸣鸟大脑中的分布：金丝雀 (Serinus canaria) 和斑胸草雀 (Taeniopygia guttata)。为了可视化 OT，我们使用先前显示可识别鸟类物种中 OT 的抗体进行了免疫细胞化学。在金丝雀和斑胸草雀中，密集的 OT-ir 核周体位于室旁核 (PVN)、视前区 (POA)、视上核 (SON) 和终纹内侧床核 (BNSTm)。我们还观察到形态不同的 OT-ir 细胞分散在整个中皮层中。在PVN、腹侧内侧下丘脑（VMH）、导水管周围灰质（PAG）、丘间核（ICo）和腹侧被盖区（VTA）中观察到OT-ir纤维。我们还在歌曲控制核 HVC 中观察到点状 OT-ir 纤维。在雄性和雌性金丝雀中，OT-ir 纤维都存在于外侧隔膜 (LS) 中，但雄性的神经支配更大。我们没有观察到斑胸草雀的这种性别差异。观察到的大部分 OT 染色与脊椎动物下丘脑内的一般分布一致，表明可能存在保守功能。然而，一些下丘脑外的分布，例如中皮层的周核分布，可能是鸣禽特有的，并在歌曲感知和产生中发挥作用。 HVC 和投射多巴胺能区域的歌曲控制核中 OT-ir 纤维的存在提供了解剖学证据，支持 OT 可以直接通过 HVC 或间接通过 PAG、VTA 或 POA 影响歌唱行为的观点。
The avian homologue of oxytocin (OT), formerly called mesotocin, influences social behaviors in songbirds and potentially song production. We sought to characterize the distribution of OT peptide in the brain of two songbird species: canaries (Serinus canaria) and zebra finches (Taeniopygia guttata). To visualize OT, we performed immunocytochemistry using an antibody previously shown to identify OT in avian species. In both canaries and zebra finches, dense OT‐ir perikarya were located in the paraventricular nucleus (PVN), preoptic area (POA), supraoptic nucleus (SON), and medial bed nucleus of the stria terminalis (BNSTm). We also observed morphologically distinct OT‐ir cells scattered throughout the mesopallium. OT‐ir fibers were observed in the PVN, ventral medial hypothalamus (VMH), periaqueductal gray (PAG), intercollicular nucleus (ICo), and ventral tegmental area (VTA). We also observed punctate OT‐ir fibers in the song control nucleus HVC. In both male and female canaries, OT‐ir fibers were present in the lateral septum (LS), but innervation was greater in males. We did not observe this sex difference in zebra finches. Much of the OT staining observed is consistent with general distributions within the vertebrate hypothalamus, indicating a possible conserved function. However, some extra‐hypothalamic distributions, such as perikarya in the mesopallium, may be specific to songbirds and play a role in song perception and production. The presence of OT‐ir fibers in HVC and song control nuclei projecting dopaminergic regions provides anatomical evidence in support of the idea that OT can influence singing behavior—either directly via HVC or indirectly via the PAG, VTA, or POA.
登录
查看更多内容
影响因子：
2.7
作者：
BONS, N
通讯作者：
BONS, N
影响因子：
1.7
作者：
Appeltants, D;Ball, GF;Balthazart, J
通讯作者：
Balthazart, J
DOI：
10.1098/rspb.2017.1114
发表时间：
2017-07-26
影响因子：
4.7
作者：
Baran, Nicole M.;Peck, Samantha C.;Adkins-Regan, Elizabeth
通讯作者：
Adkins-Regan, Elizabeth
影响因子：
3.2
作者：
Barth, SW;Bathgate, RAD;Grossmann, R
通讯作者：
Grossmann, R
影响因子：
2.5
作者：
Carouso-Peck, Samantha;Menyhart, Otilia;Goldstein, Michael H.
通讯作者：
Goldstein, Michael H.