Lack of correlation between serum soluble Fas/APO-1 levels and autoimmune disease.
Lack of correlation between serum soluble Fas/APO-1 levels and autoimmune disease.
复制标题
血清可溶性 Fas/APO-1 水平与自身免疫性疾病之间缺乏相关性。
DOI：
10.1002/art.1780381206
复制
发表时间：
1995
影响因子：
--
通讯作者：
Seldin,MF
中科院分区：
文献类型：
--
作者：
Goel,N;Ulrich,DT;StClair,EW;Fleming,JA;Lynch,DH;Seldin,MF
Objective.为了确定可溶性Fas/APO-1（sFas/APO-1）水平升高是否与自身免疫性疾病或自身免疫性疾病发作的证据相关。从正常对照和具有自身免疫性疾病活动性的实验室证据的患者中回顾性获得37份血清样本。通过酶联免疫吸附试验测定这些样本的sFas/APO-1水平，并回顾性分析患者的临床和实验室特征的医院病历。可溶性Fas/APO-1水平与临床诊断或实验室异常无关。sFas/APO-1水平在系统性红斑狼疮患者（包括活动性疾病患者）、其他自身免疫性疾病患者和正常对照组中的均值和范围相似。这些数据强烈表明，sFas/APO-1水平的测量不太可能具有临床价值或在自身免疫性疾病的发病机制中发挥作用。
Objective. To determine whether elevated soluble Fas/APO‐1 (sFas/APO‐1 ) levels are associated with either autoimmune disease or evidence of flares in autoimmune disease.Methods. Thirty‐seven serum samples were retrospectively obtained from normal controls and patients with laboratory evidence of autoimmune disease activity. These samples were assayed for sFas/APO‐1 levels by an enzyme‐linked immunosorbent assay, and hospital medical records were retrospectively reviewed for clinical and laboratory characteristics of the patients.Results. Soluble Fas/APO‐1 levels did not correlate with clinical diagnoses or laboratory abnormalities. The mean and range of sFas/APO‐1 levels were similar in systemic lupus erythematosus patients (including those with active disease), patients with other autoimmune diseases, and normal controls.Conclusion. These data strongly suggest that measurement of sFas/APO‐1 levels is unlikely to hold clinical value or play a role in the pathogenesis of autoimmune disease.
登录
查看更多内容
影响因子：
32.4
作者：
SINGER, GG;ABBAS, AK
通讯作者：
ABBAS, AK
影响因子：
56.9
作者：
CHENG, JH;ZHOU, T;MOUNTZ, JD
通讯作者：
MOUNTZ, JD
影响因子：
32.4
作者：
LYNCH, DH;WATSON, ML;SELDIN, MF
通讯作者：
SELDIN, MF
影响因子：
64.8
作者：
JU, ST;PANKA, DJ;MARSHAKROTHSTEIN, A
通讯作者：
MARSHAKROTHSTEIN, A