Effectiveness of Intravenous Infusion Algorithms for Glucose Control in Diabetic Patients Using Different Simulation Models.
Effectiveness of Intravenous Infusion Algorithms for Glucose Control in Diabetic Patients Using Different Simulation Models.
复制标题
使用不同的模拟模型，静脉输注算法对糖尿病患者的葡萄糖控制的有效性。
DOI：
10.1021/ie800871t
复制
发表时间：
2009-03-24
影响因子：
4.2
通讯作者：
Peppas, Nicholas A.
中科院分区：
文献类型：
--
作者：
Farmer, Terry G., Jr.;Edgar, Thomas F.;Peppas, Nicholas A.
闭环胰岛素输注算法的有效性进行了评估，为三个不同的数学模型，描述胰岛素和葡萄糖动力学的I型糖尿病患者。进行模拟以评估比例积分微分（PID）控制、前馈控制和基于生理的控制系统在膳食期间和运动期间维持正常葡萄糖水平方面的有效性。通过比较模拟反应与健康患者在进餐和运动期间的模拟反应，并建立最大和最小葡萄糖水平和胰岛素输注水平以及高血糖症的最长持续时间，来评估控制有效性。控制器的有效性进行评估内的最小模型，Sorensen模型，和Hovorka模型。结果表明，没有任何类型的控制是能够保持正常的条件下进行模拟时，使用最小模型。对于Sorensen模型和Hovorka模型，比例控制足以维持正常的葡萄糖水平。鉴于已发表的临床数据显示PID控制在患者中无效，这项工作表明，基于模拟结果的控制器成功可能会产生误导，未来的工作应集中在解决模型差异上。
The effectiveness of closed-loop insulin infusion algorithms is assessed for three different mathematical models describing insulin and glucose dynamics within a Type I diabetes patient. Simulations are performed to assess the effectiveness of proportional plus integral plus derivative (PID) control, feedforward control, and a physiologically-based control system with respect to maintaining normal glucose levels during a meal and during exercise. Control effectiveness is assessed by comparing the simulated response to a simulation of a healthy patient during both a meal and exercise and establishing maximum and minimum glucose levels and insulin infusion levels, as well as maximum duration of hyperglycemia. Controller effectiveness is assessed within the minimal model, the Sorensen model, and the Hovorka model. Results showed that no type of control was able to maintain normal conditions when simulations were performed using the minimal model. For both the Sorensen model and the Hovorka model, proportional control was sufficient to maintain normal glucose levels. Given published clinical data showing the ineffectiveness of PID control in patients, the work demonstrates that controller success based on simulation results can be misleading, and that future work should focus on addressing the model discrepancies.
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影响因子：
3.2
作者：
Hovorka, R;Canonico, V;Wilinska, ME
通讯作者：
Wilinska, ME
影响因子：
5.4
作者：
Bequette, B Wayne
通讯作者：
Bequette, B Wayne
胰岛素分泌数学模型及其在离体大鼠胰岛灌注中的验证
DOI：
10.1016/0010-4809(84)90021-1
发表时间：
1984-01-01
期刊：
COMPUTERS AND BIOMEDICAL RESEARCH
影响因子：
--
作者：
NOMURA, M;SHICHIRI, M;ABE, H
通讯作者：
ABE, H
影响因子：
16.2
作者：
FURLER, SM;KRAEGEN, EW;CHISHOLM, DJ
通讯作者：
CHISHOLM, DJ
影响因子：
4.6
作者：
Parker, RS;Doyle, FJ;Peppas, NA
通讯作者：
Peppas, NA