Second hand smoke exposure and the risk of invasive meningococcal disease in children: systematic review and meta-analysis.
Second hand smoke exposure and the risk of invasive meningococcal disease in children: systematic review and meta-analysis.
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二手烟雾暴露和儿童侵入性脑膜炎球菌疾病的风险：系统评价和荟萃分析。
DOI：
10.1186/1471-2458-12-1062
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发表时间：
2012-12-10
影响因子：
4.5
通讯作者：
Leonardi-Bee J
中科院分区：
文献类型：
--
作者：
Murray RL;Britton J;Leonardi-Bee J
侵袭性脑膜炎球菌病仍然是儿童和年轻人严重发病和死亡的一个重要原因。越来越多的文献表明，被动吸烟可能在疾病的发展中起作用，因此，我们进行了一项系统综述，以提供对任何家庭成员、个人家庭成员以及母亲在出生前和出生后吸烟的影响程度的全面估计。检索四个数据库（Medline, Embase， PsychINFO和CAB Abstracts数据库）以确定研究（截至2012年6月），并扫描参考文献列表以进行进一步研究。题目、摘要和全文由两位作者独立检查是否合格。采用纽卡斯尔-渥太华量表评估纳入研究的质量。使用随机效应模型估计合并优势比（OR）和95%置信区间（CI），使用I2量化异质性。我们确定了18项研究，这些研究评估了SHS对儿童侵袭性脑膜炎球菌病风险的影响。家中的SHS使侵袭性脑膜炎球菌病的风险增加了一倍（OR 2.18, 95% CI 1.63至2.92,I2 = 72%），有一些证据表明存在暴露-反应梯度。对5岁以下儿童的影响最大（OR 2.48, 95% CI 1.51 ~ 4.09, I2 = 47%）。母亲吸烟显著增加侵袭性脑膜炎球菌病的风险，怀孕期间增加3倍（OR 2.93, 95% CI 1.52-5.66），出生后增加2倍（OR 2.26, 95% CI 1.54-3.31）。接触二手烟，特别是胎儿在怀孕期间被动接触母亲吸烟，会显著增加儿童患侵袭性脑膜炎球菌病的风险。在英国家庭中，16岁以下儿童中每年有额外630例侵袭性脑膜炎球菌病可直接归因于SHS暴露。
Invasive meningococcal disease remains an important cause of serious morbidity and mortality in children and young people. There is a growing body of literature to suggest that exposure to passive smoke may play a role in the development of the disease, therefore we have performed a systematic review to provide a comprehensive estimate of the magnitude of this effect for smoking by any household member, by individual family members, and of maternal smoking before and after birth. Four databases (Medline, Embase, PsychINFO and CAB Abstracts database) were searched to identify studies (to June 2012) and reference lists scanned for further studies. Titles, abstracts and full texts were checked for eligibility independently by two authors. Quality of included studies was assessed using the Newcastle-Ottawa Scale. Pooled odds ratios (OR) with 95% confidence intervals (CI) were estimated using random effect models, with heterogeneity quantified using I2. We identified 18 studies which assessed the effects of SHS on the risk of invasive meningococcal disease in children. SHS in the home doubled the risk of invasive meningococcal disease (OR 2.18, 95% CI 1.63 to 2.92, I2 = 72%), with some evidence of an exposure-response gradient. The strongest effect was seen in children under 5 years (OR 2.48, 95% CI 1.51 to 4.09, I2 = 47%). Maternal smoking significantly increased the risk of invasive meningococcal disease by 3 times during pregnancy (OR 2.93, 95% CI 1.52-5.66) and by 2 times after birth (OR 2.26, 95% CI 1.54-3.31). SHS exposure, and particularly passive foetal exposure to maternal smoking during pregnancy, significantly increases the risk of childhood invasive meningococcal disease. It is likely that an extra 630 cases of invasive meningococcal disease annually in children under 16 are directly attributable to SHS exposure in UK homes.
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影响因子：
3.7
作者：
Duval, S;Tweedie, R
通讯作者：
Tweedie, R
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Baker, M;McNicholas, A;Lennon, D
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CAUGANT, DA;HOIBY, EA;FROHOLM, LO
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