Fabrication of micropored elastomeric film-covered stents and acute-phase performances.
Fabrication of micropored elastomeric film-covered stents and acute-phase performances.
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微孔弹性体薄膜覆盖支架的制造和急性期性能。
DOI：
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
T. Matsuda
中科院分区：
文献类型：
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作者：
Y. Nakayama;S. Nishi;H. Ueda;T. Matsuda
为了防止动脉粥样硬化血管支架植入术后急性期血栓形成和亚急性-慢性期再狭窄，我们研制了一种带有微孔弹性体膜的覆膜支架，其与血液接触的表面涂覆了一层光固化的肝素明胶。采用准分子激光微细加工技术(孔径30微米；孔间距125微米)对聚氨基甲酸乙酯(SPU)薄膜(壁厚30微米)进行微孔倍增。将二苯甲酮衍生明胶和肝素的混合水溶液涂覆在微孔SPU膜上。在紫外光照射下，用肝素固定的明胶凝胶形成一层薄层，同时固定在SPU膜上。用明胶/肝素凝胶-层状SPU膜包裹球囊可膨胀支架，然后缝合，然后粘合，组装成完全覆盖的支架。在兔颈总动脉(直径约3 mm)内植入“半覆膜”支架，其中远端一半覆盖有凝胶层SPU膜，以评估支架在体内的有效性。术后3个月，7例半覆膜支架均通畅。无论支架被覆盖或未被覆盖的区域，支架的整个管腔表面都被完全内皮化，形成了一层薄薄的新生内膜组织。讨论了上面设计的带膜支架的潜在优势。
To prevent thrombus formation in the acute phase and restenosis in the subacute to chronic phase after stenting of atherosclerotic arteries, we developed a covered stent with a micropored elastomeric film, the blood-contacting surface of which was coated with a photocured gelatin layer immobilized with heparin. Segmented polyurethane (SPU) film (30 microm in wall thickness) as a cover material was multiply micropored by excimer laser-directed microprocessing (pore diameter, 30 microm; interpore distance, 125 microm). An aqueous mixed solution of benzophenone-derivatized gelatin and heparin was coated on the micropored SPU film. Upon ultraviolet light irradiation, a thin layer of a gelatin gel immobilized with heparin was formed and simultaneously fixed on the SPU film. The fully covered stents were assembled by wrapping a balloon-expandable stent with gelatin/heparin gel-layered SPU film and subsequently suturing and then gluing. To assess the validity of this covered stent in vivo, "half-covered" stents, in which half at the distal side was covered with the gel-layered SPU film, was implanted in rabbit common carotid arteries (about 3 mm in diameter). After 3 months of implantation, all the half-covered stents (n = 7) were patent. Regardless of the covered or noncovered region of the stents, the entire luminal surface of the stents was fully endothelialized and a thin neointimal tissue was formed. The potential advantages of a covered stent as designed above are discussed.
植入犬模型的涤纶移植物细胞产生血小板衍生生长因子。
影响因子：
4.3
作者：
Pitsch,RJ;Minion,DJ;Goman,ML;vanAalst,JA;Fox,PL;Graham,LM
通讯作者：
Graham,LM
影响因子：
15.9
作者：
JAWIEN, A;BOWENPOPE, DF;CLOWES, AW
通讯作者：
CLOWES, AW