Sleep influences the intracerebral EEG pattern of focal cortical dysplasia.
Sleep influences the intracerebral EEG pattern of focal cortical dysplasia.
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DOI：
10.1016/j.eplepsyres.2015.03.014
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发表时间：
2015-07
影响因子：
2.2
通讯作者：
Frauscher B
中科院分区：
文献类型：
--
作者：
Menezes Cordeiro I;von Ellenrieder N;Zazubovits N;Dubeau F;Gotman J;Frauscher B
我们分析了FCD的脑内脑电图模式与睡眠的关系。FCD间期脑电图模式出现在分析时间的45%至97%之间。尽管几乎是连续的尖峰，睡眠是FCD脑电图模式的重要调制器。这表明发育不良的组织是受丘脑皮质控制的。局灶性皮质发育不良（FCD）能够产生以连续或近连续尖峰为特征的内在病理性脑电图活动。描述了不同的放电模式。我们定量地检查了与睡眠有关的脑内FCD模式的分布，以调查这种活动是否独立于丘脑皮质的影响。我们分析了5例诊断为FCD II型患者的第一个睡眠周期，并进行了头皮-颅内脑电图（EEG）联合检查，显示了FCD典型的颅内脑电图模式。在所有5例患者中均发现三种FCD颅内脑电图活动模式，并在每个阶段（wake, N1, N2, N3， REM）的最长30分钟内进行视觉标记：超过2hz的尖峰或多尖峰（模式1），低于2hz的平坦期中断的尖峰或多尖峰（模式2）和> - 15 Hz的低压节律性活动放电，形态规则（模式3）。标记后，计算三种模式在不同阶段的百分比。三种类型的FCD出现在分析总时间的45%至97%之间。模式1在清醒状态（73-100%）、N1（76-97%）和N2（58-88.5%）中占优势，5例患者中4例在REM状态（91-100%）中占优势。在N2和N3期间，所有患者的模式2均有所增加，在N3期间，5例患者中有3例（63-89%）成为主要模式。模式3罕见，仅在N2和N3期间零星观察到。清醒和快速眼动睡眠表现出相似的模式（模式1），快速眼动睡眠的振幅略有下降。尽管存在几乎连续放电，但睡眠是FCD II型病理性脑电图模式的重要调节因子。这可能表明发育不良的组织受到丘脑-皮层控制机制的影响，这些机制参与了睡眠的产生。
We analyze the distribution of intracerebral EEG patterns of FCD in relation to sleep. FCD interictal EEG patterns are present between 45% and 97% of the time analyzed. Despite almost continuous spiking, sleep is an important modulator of FCD EEG patterns. This suggests that dysplastic tissue is under thalamocortical control. Focal cortical dysplasia (FCD) is able to generate an intrinsic pathological EEG activity characterized by a continuous or near-continuous spiking. Different patterns of discharge were described. We examined quantitatively the distribution of the intracerebral FCD patterns in relation to sleep in order to investigate whether this activity is independent of thalamocortical influences. We analyzed the first sleep cycle of 5 patients with a diagnosis of FCD type II who underwent combined scalp-intracranial electroencephalography (EEG), and showed an intracranial EEG pattern typical for FCD. Three patterns of FCD intracranial EEG activity were identified in all 5 patients, and visually marked for a maximum of 30 min of each stage (wake, N1, N2, N3, REM): spike or polyspike exceeding 2 Hz (pattern 1), spike or polyspike interrupted by flat periods below 2 Hz (pattern 2) and discharges of >15 Hz low-voltage rhythmic activity with regular morphology (pattern 3). After marking, the percentages of the three patterns across the different stages were calculated. The three patterns of FCD were present between 45% and 97% of the total time analyzed. Pattern 1 was the predominant pattern in wakefulness (73–100%), N1 (76–97%) and N2 (58–88.5%) in all patients, and in REM in 4 of 5 patients (91–100%). During N2 and N3, there was an increase in pattern 2 in all patients, becoming the predominant pattern in 3 of the 5 patients during N3 (63–89%). Pattern 3 was rare and only sporadically observed during N2 and N3. Wakefulness and REM sleep showed a similar pattern (pattern 1) with a slight amplitude reduction in REM sleep. Despite the presence of an almost continuous discharge, sleep is an important modulator of the pathological EEG patterns found in FCD type II. This might suggest that dysplastic tissue is influenced by the thalamo-cortical control mechanisms involved in the generation of sleep.
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影响因子：
5.6
作者：
Espana, Rodrigo A.;Scammell, Thomas E.
通讯作者：
Scammell, Thomas E.
影响因子：
11.2
作者：
PALMINI, A;GAMBARDELLA, A;KIM, HI
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KIM, HI
影响因子：
11.2
作者：
Librizzi, L;de Curtis, M
通讯作者：
de Curtis, M
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9.9
作者：
Semah, F;Picot, MC;Baulac, M
通讯作者：
Baulac, M
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5.6
作者：
Chassoux, Francine;Landre, Elisabeth;Devaux, Bertrand
通讯作者：
Devaux, Bertrand