Intranasal Nanoemulsions for Direct Nose-to-Brain Delivery of Actives for CNS Disorders
Intranasal Nanoemulsions for Direct Nose-to-Brain Delivery of Actives for CNS Disorders
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DOI：
10.3390/pharmaceutics12121230
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发表时间：
2020-12-18
期刊：
影响因子：
5.4
通讯作者：
Pathak K
中科院分区：
文献类型：
--
作者：
Bahadur S;Pardhi DM;Rautio J;Rosenholm JM;Pathak K
各种中枢神经系统（CNS）疾病的治疗一直具有挑战性，尽管几种新的治疗方法的快速发展。血脑屏障（BBB）是CNS疾病治疗中的主要问题之一，在脑保护中具有主要作用，但同时构成靶向脑的药物的主要限制性障碍。在过去的几十年中，鼻药物递送已经获得了脑靶向的显著兴趣，其中药物通过三叉神经和嗅觉途径直接递送到脑。已经探索了各种新颖的和有前途的制剂方法用于通过鼻腔给药靶向脑的药物。纳米乳剂具有避免问题的潜力，包括低溶解度、差的生物利用度、缓慢起效和酶降解。本综述强调了用于鼻-脑递送的纳米乳剂用于管理根据脑部疾病分类的CNS疾病的研究方案，并进一步确定了尚未探索的领域。靶区总剂量的意义、生物分布研究和长期毒性研究已被确定为未来研究的关键领域。
The treatment of various central nervous system (CNS) diseases has been challenging, despite the rapid development of several novel treatment approaches. The blood–brain barrier (BBB) is one of the major issues in the treatment of CNS diseases, having major role in the protection of the brain but simultaneously constituting the main limiting hurdle for drugs targeting the brain. Nasal drug delivery has gained significant interest for brain targeting over the past decades, wherein the drug is directly delivered to the brain by the trigeminal and olfactory pathway. Various novel and promising formulation approaches have been explored for drug targeting to the brain by nasal administration. Nanoemulsions have the potential to avoid problems, including low solubility, poor bioavailability, slow onset of action, and enzymatic degradation. The present review highlights research scenarios of nanoemulsions for nose-to-brain delivery for the management of CNS ailments classified on the basis of brain disorders and further identifies the areas that remain unexplored. The significance of the total dose delivered to the target region, biodistribution studies, and long-term toxicity studies have been identified as the key areas of future research.
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