Consolidation of memory for odor-reward association: beta-adrenergic receptor involvement in the late phase.
Consolidation of memory for odor-reward association: beta-adrenergic receptor involvement in the late phase.
复制标题
气味奖励关联的记忆巩固：后期阶段涉及β-肾上腺素能受体。
DOI：
10.1101/lm.6.2.88
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发表时间：
1999
影响因子：
2
通讯作者：
J. Przybyslawski
中科院分区：
文献类型：
--
作者：
S. Sara;P. Roullet;J. Przybyslawski
实验中，幼稚的老鼠可以很快学会区分三种气味，以获得食物强化。经过三次大规模的试验，它们表现出几乎无误的性能。这项任务已被证明是有用的，在研究时间依赖性postacquisition长期记忆所必需的细胞内过程。本实验评估了β-去甲肾上腺素能受体在长期巩固中的作用的时间动态。老鼠被植入脑室内插管，并在一个单一的会话中训练，以找到在海绵上的一个孔中的加固物，该孔浸渍有一种特殊的气味。在训练后5分钟、1、2或5小时注射β受体拮抗剂噻吗洛尔。48小时后评估记忆和再学习能力。训练后2小时用噻吗洛尔处理的大鼠在保持测试中表现出记忆缺陷，但能够正常地重新学习任务。在较早或较晚的时间点注射无效。这些结果加强了以前的观察与全身注射，β-去甲肾上腺素能受体参与记忆巩固的后期阶段，并提出了一个关键的时间窗口，在此期间，他们是必要的。这个时间窗与目前的观点是一致的，即长期记忆依赖于cAMP级联的晚期参与，导致突触重组所需的新蛋白质合成。
Experimentally naive rats can learn rapidly to discriminate among three odors to obtain food reinforcement. After three massed trials, they show almost errorless performance. This task has proved to be useful in studying time-dependent postacquisition intracellular processes necessary for long-term memory. The present experiments evaluated the temporal dynamics of the role of beta-noradrenergic receptors in long-term consolidation. Rats were implanted with intracerebroventricular cannulae and trained in a single session to find reinforcement in a hole in a sponge impregnated with a particular odor. Injections of the beta-receptor antagonist timolol were made at 5 min, 1, 2, or 5 hr after training. Memory and relearning ability were evaluated 48 hr later. Rats treated with timolol 2 hr after training showed a memory deficit at the retention test, but were able to relearn the task normally. Injections at the earlier or later time points were ineffective. The results reinforce previous observations with systemic injections that beta-noradrenergic receptors are involved in the late phase of memory consolidation and suggest a critical time window during which they are necessary. The time window is compatible with the current view that long-term memory depends on late involvement of the cAMP cascade leading to new protein synthesis necessary for synaptic reorganization.
海马和嗅觉辨别学习：内嗅皮层损伤对连续提示、走不走任务中嗅觉学习和记忆的影响。
影响因子：
1.9
作者：
Otto,T;Schottler,F;Staubli,U;Eichenbaum,H;Lynch,G
通讯作者：
Lynch,G