Lipopolysaccharide pseudomonas vaccine: efficacy against pulmonary infection with Pseudomonas aeruginosa.
Lipopolysaccharide pseudomonas vaccine: efficacy against pulmonary infection with Pseudomonas aeruginosa.
复制标题
脂多糖假单胞菌疫苗：对铜绿假单胞菌肺部感染的功效。
DOI：
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发表时间：
1979
影响因子：
6.4
通讯作者：
J. Pennington
中科院分区：
文献类型：
--
作者：
J. Pennington
铜绿假单胞菌引起的肺炎在某些人群中发病率增加，死亡率高。用实验性肺炎假单胞菌豚鼠模型评估了接种七价脂多糖假单胞菌疫苗对呼吸道组织免受假单胞菌感染的特异性保护的潜力。动物对疫苗接种的常规反应是假单胞菌血清血凝抗体滴度上升四倍。在25只对照动物中，除9只外，其余动物在肺部感染假单胞菌后死亡，而接种疫苗的动物存活率更高（25只动物中有22只存活；P < 0.01）。在感染后的前6小时内，接种疫苗的动物肺组织中活假单胞菌的清除率明显高于对照组。肺炎假单胞菌引起的肺组织损伤在接种疫苗的动物中都比对照组少。因此，脂多糖假单胞菌疫苗似乎在呼吸组织中对假单胞菌产生局部保护反应。
Pneumonia due to Pseudomonas aeruginosa occurs with increased frequency and high mortality in certain populations of patients. The potential of vaccination with a heptavalent lipopolysaccharide pseudomonas vaccine for specific protection of respiratory tissues from infection with Pseudomonas was evaluated with a guinea pig model of experimental pseudomonas pneumonia. Animals routinely responded to vaccination with a fourfold rise in titer of serum hemagglutinating antibody to Pseudomonas. Of 25 control animals, all but nine died after lung challenge with Pseudomonas, whereas vaccinated animals had a greater survival rate (22 of 25 animals survived; P less than 0.01). Rates of clearance of viable Pseudomonas from lung tissue were significantly greater in vaccinated animals than in controls during the first 6 hr after infection. Both gross and microscopic findings of lung tissue damage from pseudomonas pneumonia were less in vaccinated than in control animals. Thus, lipopolysaccharide pseudomonas vaccine appears to produce a local protective response in respiratory tissue against Pseudomonas.
肺宿主防御。
DOI：
10.1097/00005382-199810000-00003
发表时间：
1998
期刊：
Journal of thoracic imaging.
影响因子：
--
作者：
Twigg3rd,HL
通讯作者：
Twigg3rd,HL