A review of the amino acid metabolism in placental function response to fetal loss and low birth weight in pigs.
A review of the amino acid metabolism in placental function response to fetal loss and low birth weight in pigs.
复制标题
猪胎盘功能对胎儿丢失和低出生体重反应中氨基酸代谢的综述
DOI：
10.1186/s40104-022-00676-5
复制
发表时间：
2022-03-02
影响因子：
7
通讯作者：
Yin Y
中科院分区：
文献类型：
--
作者：
Tan C;Huang Z;Xiong W;Ye H;Deng J;Yin Y
母猪的生育能力主要取决于妊娠期间胚胎的损失和产后仔猪的成活率。高产母猪的选育主要集中在高排卵指标基因型的选育上。然而，在植入早期和植入后阶段，胚胎损失率随着受精卵的增加而增加。在众多因素中，胎盘生长发育是胎儿生存、生长发育的重要决定因素。尽管胎盘发育缺陷的胎儿有可能存活，但他们的生活条件和生长可能会因称为宫内生长迟缓（IUGR）的过程而受到损害。受IUGR影响的新生仔猪发病率和死亡率容易增加；与此同时，幸存仔猪的生长、健康和福利仍将受到这些条件的阻碍，并且随着年龄的增长而加剧。甘氨酸、脯氨酸、精氨酸等功能性氨基酸随着胎盘的发育而不断增加，它们不仅是胎盘生长（包括血管生长）和发育所必需的，而且还可以作为谷胱甘肽、多胺和一氧化氮产生的底物，从多方面有益于胎盘功能。然而，这些氨基酸对胎盘功能的确切调节机制尚未阐明。在这篇综述中，我们从文献和我们自己的工作中提供了证据，证明妊娠期间日粮功能性氨基酸在调节胎盘对胎儿丢失和仔猪出生体重的功能反应中的作用和机制。这篇综述将为营养非必需氨基酸（甘氨酸和脯氨酸）对胎盘发育的反应以及提高母猪繁殖力的可行策略提供新的见解。
The fertility of sows mainly depends on the embryo losses during gestation and the survival rate of the post-farrowing piglets. The selection of highly-prolific sows has been mainly focused on the selection of genotypes with high ovulatory quota. However, in the early- and post-implantation stages, the rate of embryo losses was increased with the increase of zygotes. Among the various factors, placental growth and development is the vital determinant for fetal survival, growth, and development. Despite the potential survival of fetuses with deficient placental development, their life-conditions and growth can be damaged by a process termed intrauterine growth retardation (IUGR). The newborn piglets affected by IUGR are prone to increased morbidity and mortality rates; meanwhile, the growth, health and welfare of the surviving piglets will remain hampered by these conditions, with a tendency to exacerbate with age. Functional amino acids such as glycine, proline, and arginine continue to increase with the development of placenta, which are not only essential to placental growth (including vascular growth) and development, but can also be used as substrates for the production of glutathione, polyamines and nitric oxide to benefit placental function in many ways. However, the exact regulation mechanism of these amino acids in placental function has not yet been clarified. In this review, we provide evidence from literature and our own work for the role and mechanism of dietary functional amino acids during pregnancy in regulating the placental functional response to fetal loss and birth weight of piglets. This review will provide novel insights into the response of nutritionally nonessential amino acids (glycine and proline) to placental development as well as feasible strategies to enhance the fertility of sows.
登录
查看更多内容
影响因子：
3.8
作者：
Croy, B. A.;Wessels, J.;Tayade, C.
通讯作者：
Tayade, C.
在妊娠日粮中添加小麦糊粉可改善母猪的餐后饱腹感、应激状态和死产率
DOI：
10.1016/j.aninu.2020.06.015
发表时间：
2021-06
期刊：
Animal nutrition (Zhongguo xu mu shou yi xue hui)
影响因子：
--
作者：
Deng J;Cheng C;Yu H;Huang S;Hao X;Chen J;Yao J;Zuo J;Tan C
通讯作者：
Tan C
DOI：
10.1530/jrf.0.0760841
发表时间：
1986-03-01
期刊：
JOURNAL OF REPRODUCTION AND FERTILITY
影响因子：
--
作者：
BAZER, FW;VALLET, JL;THATCHER, WW
通讯作者：
THATCHER, WW
影响因子：
10.4
作者：
BECK, F
通讯作者：
BECK, F
影响因子：
4.2
作者：
Frank, Jason W.;Escobar, Jeffery;Wu, Guoyao
通讯作者：
Wu, Guoyao