The Impact of Visual Perceptual Learning on Sleep and Local Slow-Wave Initiation
The Impact of Visual Perceptual Learning on Sleep and Local Slow-Wave Initiation
复制标题
视觉感知学习对睡眠和局部慢波启动的影响
作者：
L. Mascetti;Vincenzo Muto;Luca Matarazzo;A. Foret;E. Ziegler;G. Albouy;V. Sterpenich;C. Schmidt;C. Degueldre;Y. Leclercq;C. Phillips;A. Luxen;G. Vandewalle;R. Vogels;P. Maquet;E. Balteau
在非快速眼动（NREM）睡眠期间，与慢波（SW）相关的突触强度的整体下降将增强随后清醒期间神经反应的信噪比。为了测试这一预测，32 名人类志愿者在早上或晚上接受了粗略方向辨别任务的培训。他们分别在清醒或睡眠 8 小时后重新进行测试。仅在一夜睡眠后，NREM SW 的丰度没有任何变化，但与训练后 NREM 睡眠期间枕外侧区“启动”的 SW 数量成比例，表现才会增强。这些波的来源与枕外侧复合体重叠，根据功能磁共振成像的评估，外侧枕复合体对习得刺激的反应在第二天早上有选择地增加。这种反应的增强与快速眼动 (REM) 睡眠持续时间成正比。这些结果提供了局部睡眠的一个例子，其中 NREM 睡眠期间局部启动 SW 预示着以后的技能提高，并预示着第二天局部神经信号的增强。此外，快速眼动睡眠还可能通过促进突触可塑性来促进局部学习依赖性活动。
During non-rapid eye movement (NREM) sleep, a global decrease in synaptic strength associated with slow waves (SWs) would enhance signal-to-noise ratio of neural responses during subsequent wakefulness. To test this prediction, 32 human volunteers were trained to a coarse orientation discrimination task, in either the morning or evening. They were retested after 8 h of wakefulness or sleep, respectively. Performance was enhanced only after a night of sleep, in the absence of any change in the abundance of NREM SWs but in proportion to the number of SWs “initiated” in lateral occipital areas during posttraining NREM sleep. The sources of these waves overlapped with the lateral occipital complex, in which responses to the learned stimulus, as assessed by fMRI, were selectively increased the next morning. This response enhancement was proportional to rapid eye movement (REM) sleep duration. These results provide an example of local sleep in which local initiation of SWs during NREM sleep predicts later skill improvement and foreshadows locally enhanced neural signals the next day. In addition, REM sleep also promotes local learning-dependent activity, possibly by promoting synaptic plasticity.
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DOI：
10.1073/pnas.92.18.8135
发表时间：
1995-08-29
影响因子：
11.1
作者：
MALACH, R;REPPAS, JB;TOOTELL, RBH
通讯作者：
TOOTELL, RBH
昼夜节律。
DOI：
10.1016/b978-0-12-571149-4.50007-6
发表时间：
1994
期刊：
Recent progress in hormone research
影响因子：
--
作者：
Turek,FW
通讯作者：
Turek,FW
影响因子：
5.9
作者：
BECK, AT;BROWN, G;STEER, RA
通讯作者：
STEER, RA
影响因子：
5.6
作者：
Riedner, Brady A.;Vyazovskiy, Vladyslav V.;Tononi, Giulio
通讯作者：
Tononi, Giulio