Is (123)I-metaiodobenzylguanidine heart-to-mediastinum ratio dependent on age? From Japanese Society of Nuclear Medicine normal database.
Is (123)I-metaiodobenzylguanidine heart-to-mediastinum ratio dependent on age? From Japanese Society of Nuclear Medicine normal database.
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DOI：
10.1007/s12149-018-1231-6
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发表时间：
2018-04
影响因子：
2.6
通讯作者：
Kinuya S
中科院分区：
文献类型：
--
作者：
Nakajima K;Okuda K;Matsuo S;Wakabayashi H;Kinuya S
123 I-间碘苄胍（MIBG）的心脏与纵隔比值（HMR）通常用于心力衰竭和路易体病的预后评估。然而，这些比率是否取决于患者年龄尚未使用正常数据库澄清。我们分析了来自日本核医学会工作组正常数据库的62例患者（平均年龄57 ± 19岁，男性45%）。根据早期（15 min）和延迟（3-4 h）前平面123 I-MIBG图像计算HMR。使用准直器类型的转换系数，将所有HMR标准化为中等能量通用（MEGP）准直器等效条件。还计算了洗脱率（WR），并分析了早期和晚期HMR以及WR是否与年龄相关。在将HMR标准化为MEGP准直器条件之前，HMR和年龄没有显著相关性。然而，晚期HMR与标准化后的年龄显著相关：晚期HMR =-0.0071 ×年龄+3.69（r2 = 0.078，p = 0.028），表明年龄增加14岁对应于HMR降低0.1。而所有患者的晚期HMR下限（2.5%分位数）为2.3，年龄≤ 63岁和> 63岁的患者分别为2.5和2.0。早期HMR倾向于在较高年龄的受试者中较低（p = 0.076），而WR不受年龄的影响。虽然老年患者的晚期HMR略有下降，但2.2-2.3的下限仍可用于确定早期和晚期HMR。
Heart-to-mediastinum ratios (HMRs) of 123I-metaiodobenzylguanidine (MIBG) have usually been applied to prognostic evaluations of heart failure and Lewy body disease. However, whether these ratios depend on patient age has not yet been clarified using normal databases. We analyzed 62 patients (average age 57 ± 19 years, male 45%) derived from a normal database of the Japanese Society of Nuclear Medicine working group. The HMR was calculated from early (15 min) and delayed (3–4 h) anterior planar 123I-MIBG images. All HMRs were standardized to medium-energy general purpose (MEGP) collimator equivalent conditions using conversion coefficients for the collimator types. Washout rates (WR) were also calculated, and we analyzed whether early and late HMR, and WR are associated with age. Before standardization of HMR to MEGP collimator conditions, HMR and age did not significantly correlate. However, late HMR significantly correlated with age after standardization: late HMR = − 0.0071 × age + 3.69 (r2 = 0.078, p = 0.028), indicating that a 14-year increase in age corresponded to a decrease in HMR of 0.1. Whereas the lower limit (2.5% quantile) of late HMR was 2.3 for all patients, it was 2.5 and 2.0 for those aged ≤ 63 and > 63 years, respectively. Early HMR tended to be lower in subjects with the higher age (p = 0.076), whereas WR was not affected by age. While late HMR was slightly decreased in elderly patients, the lower limit of 2.2–2.3 can still be used to determine both early and late HMR.
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DOI：
10.1007/s00259-007-0639-3
发表时间：
2008-03-01
影响因子：
9.1
作者：
Agostini, Denis;Verberne, Hein J.;Jacobson, Arnold F.
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DOI：
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DOI：
10.1007/s00259-014-2759-x
发表时间：
2014-09-01
影响因子：
9.1
作者：
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通讯作者：
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影响因子：
2.4
作者：
Nakajima, Kenichi;Okuda, Koichi;Yoshimura, Mana;Matsuo, Shinro;Wakabayashi, Hiroshi;Imanishi, Yasuhiro;Kinuya, Seigo
通讯作者：
Kinuya, Seigo