Mechanical Affective Touch Therapy for Anxiety Disorders: Feasibility, Clinical Outcomes, and Electroencephalography Biomarkers From an Open-Label Trial.
Mechanical Affective Touch Therapy for Anxiety Disorders: Feasibility, Clinical Outcomes, and Electroencephalography Biomarkers From an Open-Label Trial.
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DOI：
10.3389/fpsyt.2022.877574
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发表时间：
2022
影响因子：
4.7
通讯作者：
Hagberg, Sean
中科院分区：
文献类型：
--
作者：
Carpenter, Linda L.;Kronenberg, Eugenia F.;Tirrell, Eric;Kokdere, Fatih;Beck, Quincy M.;Temereanca, Simona;Fukuda, Andrew M.;Garikapati, Sahithi;Hagberg, Sean
设计用于改变情绪状态的大多数外部外周神经刺激装置使用电能，但是用于激活躯体感觉通路的机械刺激可以用于潜在的治疗性神经调节。创建了一种用于机械情感触摸治疗（MATT）的新型研究器械，通过压电致动器在双侧乳突上传递的温和振动来刺激C-触觉纤维。22名患有焦虑症和至少中度焦虑症状严重程度的成年人参加了一项开放标签的试点试验，该试验涉及在家中使用简单的耳机进行MATT自我给药，每天至少两次，持续4周。在基线MATT会话之前和之后以及在最终MATT会话之前再次采集静息EEG数据。在基线、第2周和第4周收集情绪和焦虑的自我报告测量值，同时在治疗前和治疗后评估内感受。从基线到终点，焦虑和抑郁症状显著改善，正念增强。EEG指标证实了急性MATT刺激与α和θ波段振荡功率之间的关联;症状变化与某些指标的变化相关。开放标签数据表明，MATT是一种有前途的非侵入性治疗焦虑症的方法，值得进一步开发。
Most external peripheral nerve stimulation devices designed to alter mood states use electrical energy, but mechanical stimulation for activation of somatosensory pathways may be harnessed for potential therapeutic neuromodulation. A novel investigational device for Mechanical Affective Touch Therapy (MATT) was created to stimulate C-tactile fibers through gentle vibrations delivered by piezoelectric actuators on the bilateral mastoid processes. 22 adults with anxiety disorders and at least moderate anxiety symptom severity enrolled in an open-label pilot trial that involved MATT self-administration using a simple headset at home at least twice per day for 4 weeks. Resting EEG data were acquired before and after a baseline MATT session and again before the final MATT session. Self-report measures of mood and anxiety were collected at baseline, week 2, and week 4, while interoception was assessed pre- and post-treatment. Anxiety and depressive symptoms improved significantly from baseline to endpoint, and mindfulness was enhanced. EEG metrics confirmed an association between acute MATT stimulation and oscillatory power in alpha and theta bands; symptom changes correlated with changes in some metrics. Open-label data suggest MATT is a promising non-invasive therapeutic approach to anxiety disorders that warrants further development.
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发表时间：
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影响因子：
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