Development, Morphology, and Functional Anatomy of the Olfactory Epithelium
Development, Morphology, and Functional Anatomy of the Olfactory Epithelium
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嗅上皮的发育、形态学和功能解剖学
DOI：
10.1002/9781118971758.ch4
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发表时间：
2015
影响因子：
4.4
通讯作者：
E. Morrison
中科院分区：
文献类型：
--
作者：
J. Dennis;S. Aono;V. Vodyanoy;E. Morrison
一个多世纪以来，主要嗅觉上皮(MOE)为研究神经发育的几个方面提供了一个很好的模型。本章回顾了MOE的发展和细胞结构，它是最近发现的一种保护嗅觉感觉器和鼻腔的防御机制，以及一种新的嗅觉受体神经元(ORN)信号转导的功能特性。微绒毛细胞呈神经元样形态，见于顶端神经上皮细胞。在几种神经损伤模型中，嗅鞘细胞(OECs)被证明可以促进轴突的生长和恢复，这表明它们的存在是允许和戏剧性的嗅觉轴突发生的原因。基因操作和OMP的缺失导致EOG、单细胞记录和钙成像中气味反应动力学的减慢。中枢神经系统(CNS)含有锌，其局部浓度和亚细胞隔离受到严格调控。
The main olfactory epithelium (MOE) has provided an excellent model for studying several aspects of neural development for more than a century. This chapter reviews the development and cytoarchitecture of the MOE, a recently discovered defense mechanism that protects the olfactory sensory apparatus and the nasal cavity in general, and a novel functional property of olfactory receptor neuron (ORN) signal transduction. Microvillar cells have neuron‐like morphology and are observed in the apical neuroepithelium. Olfactory ensheathing cells (OECs) have been shown to promote axon growth and recovery in several nerve lesion models, suggesting that their presence is responsible for the permissive and dramatic olfactory axogenesis. Genetic manipulations and deletion of OMP results in slower odorant response kinetics in EOG, single cell recordings, and calcium imaging. The central nervous system (CNS) contains zinc, and its local concentrations and subcellular segregation are tightly regulated.
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影响因子：
9.8
作者：
Fellermann, Klaus;Stange, Daniel E.;Stange, Eduard F.
通讯作者：
Stange, Eduard F.
影响因子：
64.8
作者：
Schroeder, Bjoern O.;Wu, Zhihong;Wehkamp, Jan
通讯作者：
Wehkamp, Jan
OMP 基因缺失会导致气味质量感知的改变。
影响因子：
1.9
作者：
Youngentob,SL;Margolis,FL;Youngentob,LM
通讯作者：
Youngentob,LM
影响因子：
3.6
作者：
Joly, S;Organ, CC;Guthmiller, JM
通讯作者：
Guthmiller, JM