OMP gene deletion results in an alteration in odorant quality perception.

OMP gene deletion results in an alteration in odorant quality perception.
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OMP 基因缺失会导致气味质量感知的改变。

DOI:
10.1037//0735-7044.115.3.626
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发表时间:
2001
影响因子:
1.9
通讯作者:
Youngentob,LM
Youngentob,LM
中科院分区:
医学4区
文献类型:
--
作者:
Youngentob,SL;Margolis,FL;Youngentob,LM

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为了验证嗅觉标记蛋白(OMP)缺失小鼠对气味质量感知发生改变的假设,我们使用5-气味识别混淆矩阵任务(动物气味混淆矩阵[AOCM])对成年OMP缺失小鼠和对照小鼠进行了训练和测试。平均而言,对照组和空白小鼠完成这项任务的水平相同。将来自每个受试者(OMP-空和对照)的40个测试会话的合成5×5反应矩阵与其他每个受试者的反应矩阵进行比较,产生AOCM反应的相异矩阵。对不同数据的多维比例(MDS)分析产生了一个4维解,每只老鼠占据MDS动物空间中的一个点。统计分析表明,基因对确定小鼠在MDS空间的位置有显著影响。因此,这些数据表明,与对照组相比,OMP缺失小鼠的气味质量感知发生了变化。
To test the hypothesis that odorant quality perception is altered in olfactory marker protein (OMP)-null mice, we trained and tested adult OMP-null and control mice, using a 5-odorant identification confusion matrix task (animal odorant confusion matrix [AOCM]). On average, control and null mice performed the task at equivalent levels. The composite 5× 5 response matrix from 40 testing sessions for each subject (both OMP-null and control) was compared with that of every other subject, yielding a dissimilarity matrix of AOCM responses. A multidimensional scaling (MDS) analysis of the dissimilarity data yielded a 4-dimensional solution, with each mouse occupying a point in MDS animal space. Statistical analysis demonstrated significant effects of genotype in determining the location of a mouse in the MDS space. These data suggest, therefore, that compared with that of controls, odorant quality perception is altered in the OMP-null mouse.
嗅觉质量的地形编码:蝾螈上皮反应性的气味特异性模式。
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