Pharmacologic and genetic strategies to enhance cell therapy for cardiac regeneration.
Pharmacologic and genetic strategies to enhance cell therapy for cardiac regeneration.
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DOI：
10.1016/j.yjmcc.2011.05.015
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发表时间：
2011-10
影响因子：
5
通讯作者：
Hare JM
中科院分区：
文献类型：
--
作者：
Kanashiro-Takeuchi RM;Schulman IH;Hare JM
基于细胞的治疗方法正在成为心肌梗死（MI）后心脏再生的一种令人兴奋的潜在治疗方法。随着心力衰竭（HF）患病率的增加，开发新的干预措施来帮助心脏从损伤中恢复是至关重要的，应该更广泛地考虑。在这方面，提高细胞治疗的有效性和安全性的大量努力在几个方面不断增长，包括修改以提高诱导多能干细胞（iPS）的重编程效率，成体干细胞的基因工程，以及使用生长因子或小分子来激活损伤心脏的再生途径。基于其促进干细胞归巢、增殖、分化和/或存活的潜力，这些干预措施正在成为潜在的治疗替代方案和/或辅助手段。鉴于治疗干预有望增强多能干细胞的再生能力，以及特异性引导内源性或外源性干细胞进入心脏谱系，它们在心脏再生医学中的应用应该是未来临床研究的重点。本文是题为“关键信号分子特刊”的特刊的一部分。
Cell-based therapy is emerging as an exciting potential therapeutic approach for cardiac regeneration following myocardial infarction (MI). As heart failure (HF) prevalence increases over time, development of new interventions designed to aid cardiac recovery from injury are crucial and should be considered more broadly. In this regard, substantial efforts to enhance the efficacy and safety of cell therapy are continuously growing along several fronts, including modifications to improve the reprogramming efficiency of inducible pluripotent stem cells (iPS), genetic engineering of adult stem cells, and administration of growth factors or small molecules to activate regenerative pathways in the injured heart. These interventions are emerging as potential therapeutic alternatives and/or adjuncts based on their potential to promote stem cell homing, proliferation, differentiation, and/or survival. Given the promise of therapeutic interventions to enhance the regenerative capacity of multipotent stem cells as well as specifically guide endogenous or exogenous stem cells into a cardiac lineage, their application in cardiac regenerative medicine should be the focus of future clinical research. This article is part of a Special Issue entitled ‘Key Signaling Molecules Special Issue’.
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用白藜芦醇修饰的心脏干细胞再生梗塞心肌的再生。
影响因子：
5.3
作者：
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影响因子：
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影响因子：
6.6
作者：
Burlacu, Alexandrina;Rosca, Ana-Maria;Simionescu, Maya
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影响因子：
37.8
作者：
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影响因子：
82.9
作者：
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