Arterial wall thickening normalizes arterial wall tension with growth in American alligators, Alligator mississippiensis
Arterial wall thickening normalizes arterial wall tension with growth in American alligators, Alligator mississippiensis
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随着美洲短吻鳄（密西西比短吻鳄）的生长，动脉壁增厚使动脉壁张力正常化
DOI：
10.1007/s00360-021-01353-1
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Crossley, Dane A.
中科院分区：
文献类型：
--
作者：
Filogonio, Renato;Dubansky, Benjamin D.;Dubansky, Brooke H.;Wang, Tobias;Elsey, Ruth M.;Leite, Cléo A.;Crossley, Dane A.
动脉壁张力随着管腔半径和动脉压的增加而增加。因此，随着身体质量（Mb）增加，半径的相关增加引起更大的张力。因此，可以预测，高张力将增加动脉壁破裂的可能性。对哺乳动物的研究集中在全身动脉上，并表明动脉壁厚度随着M的增加而增加，并且使张力正常化。爬行动物是很好的模型来研究缩放，因为一些物种表现出与生长相关的大的身体尺寸范围，因此，允许个体发育比较。我们使用孵化后的美国短吻鳄，密西西比短吻鳄，从0.12到6.80公斤（约60倍），以研究右主动脉弓（RAo）和左肺动脉（LPA）如何随着Mb的变化而变化。我们测试了两种可能性：（i）壁厚随M带的增加而增加，使壁张力正常化，使得应力（应力=张力/厚度）保持不变;（ii）胶原含量随M带的增加而增加，动脉强度。我们测量了麻醉动物的心率、体循环和肺循环的收缩压和平均压。一旦鳄鱼稳定下来，就给它注射肾上腺素，以引起与生理相关的压力增加。随着Mb的增加，心率降低，体循环压升高;肺动脉压保持不变。在生理静水压力下，RAo和LPA均保持不变，随着Mb的增加，RAo和LPA的半径、壁张力和厚度均增大，因此，应力与Mb无关，相对胶原含量不变。我们的结论是，增加壁厚正常化的紧张局势，并减少了动脉壁破裂的机会，在大型鳄鱼。
Arterial wall tension increases with luminal radius and arterial pressure. Hence, as body mass (Mb) increases, associated increases in radius induces larger tension. Thus, it could be predicted that high tension would increase the potential for rupture of the arterial wall. Studies on mammals have focused on systemic arteries and have shown that arterial wall thickness increases withMband normalizes tension. Reptiles are good models to study scaling because some species exhibit large body size range associated with growth, thus, allowing for ontogenetic comparisons. We used post hatch American alligators,Alligator mississippiensis, ranging from 0.12 to 6.80 kg (~ 60-fold) to investigate how both the right aortic arch (RAo) and the left pulmonary artery (LPA) change withMb. We tested two possibilities: (i) wall thickness increases withMband normalizes wall tension, such that stress (stress = tension/thickness) remains unchanged; (ii) collagen content scales withMband increases arterial strength. We measured heart rate and systolic and mean pressures from both systemic and pulmonary circulations in anesthetized animals. Once stabilized alligators were injected with adrenaline to induce a physiologically relevant increase in pressure. Heart rate decreased and systemic pressures increased withMb; pulmonary pressures remained unchanged. Both the RAo and LPA were fixed under physiological hydrostatic pressures and displayed larger radius, wall tension and thickness asMbincreased, thus, stress was independent fromMb; relative collagen content was unchanged. We conclude that increased wall thickness normalizes tension and reduces the chances of arterial walls rupturing in large alligators.
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影响因子：
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作者：
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DOI：
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