Does mean arterial blood pressure scale with body mass in mammals? Effects of measurement of blood pressure
Does mean arterial blood pressure scale with body mass in mammals? Effects of measurement of blood pressure
复制标题
哺乳动物的平均动脉血压与体重成正比吗？
作者：
C. B. Poulsen;Tobias Wang;Kasper B Assersen;Nina K Iversen;M. Damkjær
至少在过去的30年里，人们一直在讨论平均动脉血压（MAP）是否与体重无关，或者它是否根据心脏和大脑之间的垂直高度而增加。辩论集中在最合适的数学模型分析异速生长和系统发育的关系，有以前很少关注评估的有效性基本生理数据。目前，两个最全面的尺度分析是基于47种哺乳动物的数据，基于114个参考文献。我们回顾了所有可用的参考文献，以确定在何种生理条件下MAP已被记录。在44篇（38.6%）引用的参考文献中，在麻醉动物中测量MAP。59篇（51.8%）参考文献报告了清醒动物的数据;其中3篇（2.6%）为无线电遥测研究。在5个物种中，报告了麻醉和清醒动物的数据，这些设置之间的MAP平均差异为20 ± 29 mm Hg。通过文献检索，我们确定了Meta分析中纳入的47个物种中的11个物种通过无线电遥测进行的MAP测量。Bland-Altman分析显示偏倚为1 mm Hg，置信区间为95%（-35至36 mm Hg）;也就是说，无线电遥测研究与束缚动物研究之间的一致性限度是小鼠和大象之间MAP的假设差异的两倍。总之，现有的文献没有提供证据，无论是积极的或中性缩放的动脉压，以身体质量跨类群。
For at least the last 30 years, it has been discussed whether mean arterial blood pressure (MAP) is independent of body mass or whether it increases in accordance with the vertical height between the heart and the brain. The debate has centred on the most appropriate mathematical models for analysing allometric scaling and phylogenetic relationships; there has been previously little focus on evaluating the validity of underlying physiological data. Currently, the 2 most comprehensive scaling analyses are based on data from 47 species of mammals, based on 114 references. We reviewed all available references to determine under which physiological conditions MAP had been recorded. In 44 (38.6%) of the cited references, MAP was measured in anaesthetized animals. Data from conscious animals were reported in 59 (51.8%) of references; of these, 3 (2.6%) were radiotelemetric studies. In 5 species, data were reported from both anaesthetized and conscious animals, and the mean difference in the MAP between these settings was 20 ± 29 mm Hg. From a literature search, we identified MAP measurements performed by radiotelemetry in 11 of the 47 species included in the meta‐analyses. A Bland‐Altman analysis showed a bias of 1 mm Hg with 95% confidence interval (from −35 to 36 mm Hg); that is, the limits of agreement between radiotelemetric studies and studies in restrained animals were double the supposed difference in the MAP between the mouse and elephant. In conclusion, the existing literature does not provide evidence for either a positive or neutral scaling of arterial pressure to body mass across taxa.
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DOI：
10.1152/ajpendo.00668.2006
发表时间：
2007-06-01
影响因子：
5.1
作者：
King, Andrew J.;Olivier, N. Bari;Fink, Gregory D.
通讯作者：
Fink, Gregory D.
慢性压力超负荷肥大会降低直接心室相互作用。
DOI：
10.1152/ajpheart.1987.253.2.h347
发表时间：
1987
期刊：
The American journal of physiology
影响因子：
--
作者：
Slinker,BK;Chagas,AC;Glantz,SA
通讯作者：
Glantz,SA
影响因子：
15.9
作者：
Liu, YH;Yang, XP;Carretero, OA
通讯作者：
Carretero, OA
行为引起雌性食蟹猴（猕猴）的心率反应性和动脉粥样硬化。
影响因子：
3.3
作者：
Manuck,SB;Kaplan,JR;Adams,MR;Clarkson,TB
通讯作者：
Clarkson,TB
DOI：
10.1152/ajpregu.1998.274.2.r564
发表时间：
1998-02-01
影响因子：
2.8
作者：
Mattson, DL
通讯作者：
Mattson, DL