The aging kidney and the nephrotoxic effects of mercury.
The aging kidney and the nephrotoxic effects of mercury.
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DOI：
10.1080/10937404.2016.1243501
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Zalups RK
中科院分区：
文献类型：
--
作者：
Bridges CC;Zalups RK
由于现代医学的进步，预期寿命正在延长，并导致老年人口的增加。衰老过程导致许多器官系统发生重大变化，肾脏尤其容易受到与年龄相关的变化的影响。在肾脏内，衰老导致超微结构改变，如肾小球和小管肥大、肾小球硬化和小管间质纤维化，这些改变可能会损害肾血浆流量（RPF）和肾小球滤过率（GFR）。这些改变可能会降低肾脏的功能储备，使其在受到挑战或压力时更容易受到病理事件的影响，例如暴露于肾毒物。汞是引起肾毒性作用的一种重要和普遍的环境毒物。由于正常肾脏暴露于汞离子可能诱发肾小球和肾小管损伤，老年肾脏可能不能完全发挥功能，因此对汞的影响可能比正常肾脏更敏感。与年龄相关的肾脏变化和汞对肾脏的影响已被分别表征。然而，关于肾毒性物质（如汞）对老年肾脏的影响知之甚少。这篇综述的目的是总结与暴露于环境相关肾毒物汞的老年和病变肾脏相关的已知发现。
Owing to advances in modern medicine, life expectancies are lengthening and leading to an increase in the population of older individuals. The aging process leads to significant alterations in many organ systems, with the kidney being particularly susceptible to age-related changes. Within the kidney, aging leads to ultrastructural changes such as glomerular and tubular hypertrophy, glomerulosclerosis, and tubulointerstitial fibrosis, which may compromise renal plasma flow (RPF) and glomerular filtration rate (GFR). These alterations may reduce the functional reserve of the kidneys making them more susceptible to pathological events when challenged or stressed, such as following exposure to nephrotoxicants. An important and prevalent environmental toxicant that induces nephrotoxic effects is mercury (Hg). Since, exposure of normal kidneys to mercuric ions might induce glomerular and tubular injury, aged kidneys, which may not be functioning at full capacity, may be more sensitive to the effects of Hg than normal kidneys. Age-related renal changes and the effects of Hg in the kidney have been characterized separately. However, little is known regarding the influence of nephrotoxicants, such as Hg, on aged kidneys. The purpose of this review was to summarize known findings related to exposure of aged and diseased kidneys to the environmentally relevant nephrotoxicant, Hg.
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影响因子：
3.3
作者：
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DOI：
10.1080/15287394.2016.1149130
发表时间：
2016-03-03
影响因子：
2.6
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通讯作者：
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