Aetiology: Koch's postulates fulfilled for SARS virus.

Aetiology: Koch's postulates fulfilled for SARS virus.
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Aetiology:Koch的假设对SARS病毒实现。

DOI:
10.1038/423240a
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发表时间:
2003-05-15
期刊:
影响因子:
64.8
通讯作者:
Osterhaus AD
Osterhaus AD
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Fouchier RA;Kuiken T;Schutten M;van Amerongen G;van Doornum GJ;van den Hoogen BG;Peiris M;Lim W;Stöhr K;Osterhaus AD

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严重急性呼吸系统综合症(SARS)最近成为一种新的人类疾病,导致全球6234例疑似病例中的435人死亡(截至2003年5月3日)。在这里,我们提供了实验感染食蟹猴(猕猴)的证据,证明新发现的SARS相关冠状病毒(SCV)是这种疾病的病原体。我们对SARS病原学的了解将加快诊断测试、抗病毒治疗和疫苗的开发,并可能为这种新出现的疾病提供更简洁的病例定义。本文的在线版本(doi:10.1038/423240a)包含补充材料,授权用户可以使用。
Severe acute respiratory syndrome (SARS) has recently emerged as a new human disease, resulting globally in 435 deaths from 6,234 probable cases (as of 3 May 2003). Here we provide proof from experimental infection of cynomolgus macaques (Macaca fascicularis) that the newly discovered SARS-associated coronavirus (SCV) is the aetiological agent of this disease. Our understanding of the aetiology of SARS will expedite the development of diagnostic tests, antiviral therapies and vaccines, and may allow a more concise case definition for this emerging disease. The online version of this article (doi:10.1038/423240a) contains supplementary material, which is available to authorized users.
DOI: 10.1038/89098
发表时间: 2001-06
期刊: Nature medicine
影响因子: 82.9
作者:
van den Hoogen BG;de Jong JC;Groen J;Kuiken T;de Groot R;Fouchier RA;Osterhaus AD
通讯作者: Osterhaus AD
DOI: 10.1016/s0140-6736(03)13077-2
发表时间: 2003-04-19
期刊: Lancet (London, England)
影响因子: --
作者:
Peiris JS;Lai ST;Poon LL;Guan Y;Yam LY;Lim W;Nicholls J;Yee WK;Yan WW;Cheung MT;Cheng VC;Chan KH;Tsang DN;Yung RW;Ng TK;Yuen KY;SARS study group
通讯作者: SARS study group