A newly discovered human pneumovirus isolated from young children with respiratory tract disease.
A newly discovered human pneumovirus isolated from young children with respiratory tract disease.
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DOI：
10.1038/89098
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发表时间：
2001-06
期刊：
影响因子：
82.9
通讯作者：
Osterhaus AD
中科院分区：
文献类型：
--
作者：
van den Hoogen BG;de Jong JC;Groen J;Kuiken T;de Groot R;Fouchier RA;Osterhaus AD
从荷兰的28名幼儿中，我们分离出一种副粘病毒，根据病毒学数据、序列同源性和基因星座，该病毒被鉴定为偏肺病毒属的暂定新成员。在此之前，禽肺炎病毒是这一新发现的属的唯一成员，因此新发现的病毒的临时名称为：人偏肺病毒。分离出病毒的患儿临床症状与人呼吸道合胞病毒感染引起的症状相似，从上呼吸道疾病到严重的细支气管炎和肺炎。血清学研究表明，荷兰几乎所有五岁以下儿童都接触过人类偏肺病毒，该病毒在人类中传播至少50年。
From 28 young children in the Netherlands, we isolated a paramyxovirus that was identified as a tentative new member of the Metapneumovirus genus based on virological data, sequence homology and gene constellation. Previously, avian pneumovirus was the sole member of this recently assigned genus, hence the provisional name for the newly discovered virus: human metapneumovirus. The clinical symptoms of the children from whom the virus was isolated were similar to those caused by human respiratory syncytial virus infection, ranging from upper respiratory tract disease to severe bronchiolitis and pneumonia. Serological studies showed that by the age of five years, virtually all children in the Netherlands have been exposed to human metapneumovirus and that the virus has been circulating in humans for at least 50 years.
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影响因子：
14.9
作者：
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通讯作者：
MCCLELLAND, M
影响因子：
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