T cell receptor-instructed alphabeta versus gammadelta lineage commitment revealed by single-cell analysis.
T cell receptor-instructed alphabeta versus gammadelta lineage commitment revealed by single-cell analysis.
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通过单细胞分析揭示了T细胞受体指导的字母与γ谱系的承诺。
DOI：
10.1084/jem.20072425
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发表时间：
2008-05-12
影响因子：
15.3
通讯作者：
von Boehmer, Harald
中科院分区：
文献类型：
--
作者：
Kreslavsky, Taras;Garbe, Annette I.;Krueger, Andreas;von Boehmer, Harald
αβ和γδ T细胞谱系在胸腺中从共同的前体发育。目前尚不清楚在发育的哪个阶段发生对这些谱系的承诺，以及T细胞受体信号传导以何种方式促成这一过程。最近，证明强TCR信号有利于γδ谱系发育，而弱TCR信号促进αβ谱系命运。已经提出了两个模型来解释这些结果。第一个模型表明，定型发生在TCR表达后，TCR信号直接指示淋巴细胞采用一种或另一种谱系命运。第二个模型表明，承诺发生在TCR表达之前，TCR信号传导仅仅确认谱系选择。通过追踪单个T细胞前体的命运，该研究表明在TCR表达之前不存在对αβ或γδ谱系的定型，并且在单个TCR表达细胞的后代中TCR信号传导的调节改变谱系定型。
αβ and γδ T cell lineages develop in the thymus from a common precursor. It is unclear at which stage of development commitment to these lineages takes place and in which way T cell receptor signaling contributes to the process. Recently, it was demonstrated that strong TCR signals favor γδ lineage development, whereas weaker TCR signals promote αβ lineage fate. Two models have been proposed to explain these results. The first model suggests that commitment occurs after TCR expression and TCR signaling directly instructs lymphocytes to adopt one or the other lineage fate. The second model suggests that commitment occurs before TCR expression and that TCR signaling merely confirms the lineage choice. By tracing the fate of single T cell precursors, this study shows that there is no commitment to either the αβ or γδ lineage before TCR expression and that modulation of TCR signaling in progeny of a single TCR-expressing cell changes lineage commitment.
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DOI：
10.1084/jem.192.4.537
发表时间：
2000-08-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Terrence K;Pavlovich CP;Matechak EO;Fowlkes BJ
通讯作者：
Fowlkes BJ
影响因子：
32.4
作者：
Ciofani, Maria;Knowles, Gisele C.;Zuniga-Pflucker, Juan Carlos
通讯作者：
Zuniga-Pflucker, Juan Carlos
影响因子：
32.4
作者：
Bruno, L;Fehling, HJ;vonBoehmer, H
通讯作者：
vonBoehmer, H
影响因子：
15.3
作者：
Garbe, Annette I.;Krueger, Andreas;von Boehmer, Harald
通讯作者：
von Boehmer, Harald
影响因子：
4.4
作者：
Wilson, A;Capone, M;MacDonald, HR
通讯作者：
MacDonald, HR