Spatial segregation of adaptation and predictive sensitization in retinal ganglion cells.
Spatial segregation of adaptation and predictive sensitization in retinal ganglion cells.
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DOI：
10.1016/j.neuron.2013.06.011
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发表时间：
2013-08-07
期刊：
影响因子：
16.2
通讯作者：
Baccus SA
中科院分区：
文献类型：
--
作者：
Kastner DB;Baccus SA
感觉系统根据最近的刺激改变它们的灵敏度，以调整它们对输入范围的反应范围，并预测未来的感觉输入。在这里，我们报告了具有拮抗可塑性的视网膜神经节细胞的存在，表现出中枢适应和外周敏化。神经节细胞反应被一个时空模型捕获，该模型具有独立适应的兴奋和抑制亚基，并且敏化需要gaba能抑制。利用一个简单的信号检测理论，我们证明了敏化环绕符合一个不断更新先验信号概率的最优推理模型。这表明小的接受野区域具有双重功能——适应局部范围的信号，但根据该信号存在的概率进行敏感化。在这个框架内，我们发现敏化预测了附近物体的位置，揭示了预测作为神经系统中适应性抑制的新功能角色。
Sensory systems change their sensitivity based upon recent stimuli to adjust their response range to the range of inputs, and to predict future sensory input. Here we report the presence of retinal ganglion cells that have antagonistic plasticity, showing central adaptation and peripheral sensitization. Ganglion cell responses were captured by a spatiotemporal model with independently adapting excitatory and inhibitory subunits, and sensitization requires GABAergic inhibition. Using a simple theory of signal detection we show that the sensitizing surround conforms to an optimal inference model that continually updates the prior signal probability. This indicates that small receptive field regions have dual functionality—to adapt to the local range of signals, but sensitize based upon the probability of the presence of that signal. Within this framework, we show that sensitization predicts the location of a nearby object, revealing prediction as a new functional role for adapting inhibition in the nervous system.
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影响因子：
1.9
作者：
Geisler, Wilson S.;Perry, Jeffrey S.
通讯作者：
Perry, Jeffrey S.
影响因子：
64.8
作者：
Berry, MJ;Brivanlou, IH;Meister, M
通讯作者：
Meister, M
影响因子：
5.5
作者：
BARLOW, HB
通讯作者：
BARLOW, HB
DOI：
10.1523/jneurosci.2631-11.2011
发表时间：
2011-07-27
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Jarsky T;Cembrowski M;Logan SM;Kath WL;Riecke H;Demb JB;Singer JH
通讯作者：
Singer JH
影响因子：
16.2
作者：
Baccus, SA;Meister, M
通讯作者：
Meister, M