The association of malaria infection and gestational hypertension in Africa: Systematic review and meta-analysis.
The association of malaria infection and gestational hypertension in Africa: Systematic review and meta-analysis.
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DOI：
10.7189/jogh.10.020417
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发表时间：
2020-12
影响因子：
7.2
通讯作者：
Norrie J
中科院分区：
文献类型：
--
作者：
Mruma HA;McQuillan R;Norrie J
世界卫生组织(WHO)估计，妊娠期高血压疾病(HDP)占全球孕产妇死亡率的14%。HDP包括几个亚类，包括妊娠期高血压(GH)和先兆子痫。这两种情况的特点都是血压升高，从怀孕20周开始起效。他们也有一些共同的风险因素。目前对子痫前期的定义包括无蛋白尿时血压升高，因此将这两种情况呈现为一种谱系。在本文中，我们将这两种情况称为妊娠期高血压，这是我们感兴趣的结果。生长激素的病因尚不清楚。观察性研究表明，疟疾可能与生长激素有关。然而，这些小规模研究的证据一直没有定论。更好地了解疟疾和生长激素之间的联系可能有助于制定预防战略，以降低孕产妇和婴儿死亡率和发病率。在评估疟疾感染和生长激素之间的关系时，我们探索了Medline、Embase、WHO GIM和Google Shoorer上发表的英文开放获取文章。根据系统回顾和荟萃分析(PRISMA)指南中的首选报告项目检索和处理与主题相关的文章。搜索日期是2018年第9周。使用Revman 5软件(Cochrane Collaboration，伦敦，英国)中的逆方差加权方法，通过计算合并的优势比来汇总证据，以显示疟疾和GH之间关系的性质和强度。使用关键评估技能计划(CASP)检查表工具，我们确定了四项高质量的病例对照研究。总样本量为1281名女性，其中518名为病例。这些研究一起表明疟疾与生长激素有关，总体优势比为2.67，95%可信区间(CI) = 为1.58-4.53。个体研究的异质性支持固定效应模型假设(I2 = 0%)。疟疾感染可能会对非洲不同人群的生长激素产生持续影响。漏斗图并不表明存在发表偏见，然而，荟萃分析中涉及的四项研究不足以排除这一可能性。我们的发现提供了疟疾感染和妊娠期高血压之间存在关联的证据；这强调了控制疟疾的必要性，特别是在怀孕期间。
The World Health Organisation (WHO) estimates that hypertensive disorders of pregnancy (HDP) contribute 14% to global maternal mortality. HDP encompasses several subcategories, including gestational hypertension (GH) and pre-eclampsia. These two conditions are both characterised by a rise in blood pressure, with an onset from 20 weeks of gestation. They also share some common risk factors. The current definition of pre-eclampsia includes raised blood pressure in the absence of proteinuria, thus presenting the two conditions as a spectrum. In this article, we refer to both conditions as gestational hypertension, which is our outcome of interest. The aetiology of GH is not yet clearly understood. Observational studies have suggested that malaria may be associated with GH. However, the evidence from these small studies has been inconclusive. Having a better understanding of the association between malaria and GH may help inform prevention strategies to reduce maternal and infant mortality and morbidity. In assessing the association between malaria infection and GH we explored open access articles published in the English language on Medline, Embase, WHO GIM and Google scholar. The subject related articles were retrieved and processed according to preferred reporting items in systematic reviews and meta-analyses (PRISMA) guidelines. Search date was 9th week of 2018. Inverse variance weighting method in Revman 5 software (Cochrane Collaboration, London, United Kingdom) was used to aggregate evidence by computing the pooled odds ratio to show the nature and strength of the relationship between malaria and GH. Using critical appraisal skills program (CASP) checklist tool we identified four good quality case-control studies. The total sample size was 1281 women out of which 518 were cases. These studies together show malaria is associated with GH with an overall odds ratio of 2.67, 95% confidence interval (CI) = 1.58-4.53. Heterogeneity of the individual studies supported fixed effect modelling assumptions (I2 = 0%). Malaria infection may have a constant effect on GH across different African populations. The funnel plot did not suggest publication bias however, the four studies involved in the meta-analysis were insufficient to rule it out. Our findings provide evidence of an association between malaria infection and gestational hypertension; this underscores the need to control malaria especially during pregnancy.
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DOI：
10.1161/hypertensionaha.116.07099
发表时间：
2016-06
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Egeland GM;Klungsøyr K;Øyen N;Tell GS;Næss Ø;Skjærven R
通讯作者：
Skjærven R
影响因子：
9.3
作者：
Moore KA;Simpson JA;Wiladphaingern J;Min AM;Pimanpanarak M;Paw MK;Raksuansak J;Pukrittayakamee S;Fowkes FJI;White NJ;Nosten F;McGready R
通讯作者：
McGready R
影响因子：
168.9
作者：
Liu, Li;Oza, Shefali;Hogan, Dan;Chu, Yue;Perin, Jamie;Zhu, Jun;Lawn, Joy E.;Cousens, Simon;Mathers, Colin;Black, Robert E.
通讯作者：
Black, Robert E.
影响因子：
3.1
作者：
Ephraim RK;Osakunor DN;Denkyira SW;Eshun H;Amoah S;Anto EO
通讯作者：
Anto EO
影响因子：
34.3
作者：
Say, Lale;Chou, Doris;Alkema, Leontine
通讯作者：
Alkema, Leontine