Serum calcium and magnesium levels in women presenting with pre-eclampsia and pregnancy-induced hypertension: a case-control study in the Cape Coast metropolis, Ghana.
Serum calcium and magnesium levels in women presenting with pre-eclampsia and pregnancy-induced hypertension: a case-control study in the Cape Coast metropolis, Ghana.
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DOI：
10.1186/s12884-014-0390-2
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发表时间：
2014-11-20
影响因子：
3.1
通讯作者：
Anto EO
中科院分区：
文献类型：
--
作者：
Ephraim RK;Osakunor DN;Denkyira SW;Eshun H;Amoah S;Anto EO
妊娠期高血压疾病是导致发病和死亡的重要原因。妊娠期钙（Ca2+）和镁（Mg2+）水平可能与它们在妊娠高血压中的可能作用有关。本研究评估了PIH（妊娠性高血压）和PE（子痫前期）妇女与正常妊娠妇女的血清Ca2+和Mg2+水平。本病例对照研究对在加纳海岸角大都会的三家医院接受产前护理的380名孕妇（妊娠≥20周）进行了研究。其中包括120名妊高征妇女、100名妊高征妇女和160名年龄匹配的健康孕妇（对照组）。使用基于访谈的问卷收集了人口统计学、人体测量学、临床和产科数据。取静脉血测定钙、镁含量。PIH和PE患者的收缩压（SBP）和舒张压（DBP）均显著升高（p < 0.0001）。有高血压疾病（PE和PIH）的妇女血清钙和镁水平明显低于对照组（p < 0.0001）。PIH患者SBP与BMI呈正相关（r = 0.575, p < 0.01）， Ca2+与Mg2+呈正相关（r = 0.494, p < 0.01）。在PE组中，收缩压和BMI以及Ca2+和Mg2+的情况相似，但不显著。多因素分析显示，年龄≥40岁的女性发生PIH的风险显著（OR = 2.14, p = 0.000）。在本研究人群中，妊高征和妊高征的血清钙和镁水平低于正常妊娠。产前补充矿物质可显著影响妊娠期高血压疾病的发生。
Hypertensive disorders of pregnancy are important causes of morbidity and mortality. The levels of calcium (Ca2+) and magnesium (Mg2+) in pregnancy may implicate their possible role in pregnancy-induced hypertension. This study assessed serum Ca2+ and Mg2+ levels in women with PIH (pregnancy-induced hypertension) and PE (pre-eclampsia), compared to that in normal pregnancy. This case–control study was conducted on 380 pregnant women (≥20 weeks gestation) receiving antenatal care at three hospitals in the Cape Coast metropolis, Ghana. This comprised 120 women with PIH, 100 women with PE and 160 healthy, age-matched pregnant women (controls). Demographic, anthropometric, clinical and obstetric data were gathered using an interview-based questionnaire. Venous blood samples were drawn for the estimation of calcium and magnesium. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were significantly raised in women with PIH (p < 0.0001) and PE (p < 0.0001). Women with hypertensive disorders (PE and PIH) had significantly lower serum calcium and magnesium levels than those in the control group (p < 0.0001 each). Of those with PIH, SBP correlated positively with BMI (r = 0.575, p < 0.01) and Ca2+ correlated positively with Mg2+ (r = 0.494, p < 0.01). This was similar amongst the PE group for SBP and BMI as well as for Ca2+and Mg2+ but was not significant. Multivariate analysis showed that women aged ≥40 years were at a significant risk of developing PIH (OR = 2.14, p = 0.000). In this study population, serum calcium and magnesium levels are lower in PIH and PE than in normal pregnancy. Mineral supplementation during the antenatal period may influence significantly, the occurrence of hypertensive disorders in pregnancy.
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影响因子：
3.2
作者：
Osungbade KO;Ige OK
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影响因子：
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