Do Epigenetic Clocks Provide Explanations for Sex Differences in Life Span? A Cross-Sectional Twin Study.
Do Epigenetic Clocks Provide Explanations for Sex Differences in Life Span? A Cross-Sectional Twin Study.
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DOI：
10.1093/gerona/glab337
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发表时间：
2022-09-01
影响因子：
5.1
通讯作者：
Sillanpaa, Elina
中科院分区：
文献类型：
--
作者：
Kankaanpaa, Anna;Tolvanen, Asko;Saikkonen, Pirkko;Heikkinen, Aino;Laakkonen, Eija K.;Kaprio, Jaakko;Ollikainen, Miina;Sillanpaa, Elina
在过去的4-50年里，芬兰的预期寿命方面的性别差距一直在缩小；然而，平均而言，女性的寿命仍然比男性长。表观遗传时钟是生物衰老的标志，可以预测寿命。在这项研究中，我们考察了生活方式因素在年轻人和老年人的性别和生物衰老之间的联系中的中介作用。我们的样本包括年轻和年长的双胞胎(21-42岁，n=1477；50-76岁，n=763)，包括151对完整的年轻异性双胞胎(21-30岁)。基于血液的DNA甲基化被用来计算4个表观遗传时钟的表观遗传年龄加速，作为生物老化的衡量标准。路径模型被用来研究性和生物衰老之间的联系是否通过与生活方式相关的因素来调节，即教育、体重指数、吸烟、饮酒和体育活动。与女性相比，男性的生理年龄更大，总体来说，他们的生活习惯更不健康。性别对生物衰老的影响在一定程度上是通过体重指数来调节的，对于年龄较大的双胞胎来说，则是通过吸烟来调节的。性别与生理衰老直接相关，这种关联在双胞胎中更强。此前报道的寿命性别差异在生物衰老方面也很明显。男性吸烟率的下降是两性预期寿命差异缩小的合理解释。表观遗传时钟产生的数据可能有助于估计生活方式和环境因素对衰老的影响，并预测未来几代人的衰老。
The sex gap in life expectancy has been narrowing in Finland over the past 4–5 decades; however, on average, women still live longer than men. Epigenetic clocks are markers for biological aging which predict life span. In this study, we examined the mediating role of lifestyle factors on the association between sex and biological aging in younger and older adults. Our sample consists of younger and older twins (21‒42 years, n = 1 477; 50‒76 years, n = 763) including 151 complete younger opposite-sex twin pairs (21‒30 years). Blood-based DNA methylation was used to compute epigenetic age acceleration by 4 epigenetic clocks as a measure of biological aging. Path modeling was used to study whether the association between sex and biological aging is mediated through lifestyle-related factors, that is, education, body mass index, smoking, alcohol use, and physical activity. In comparison to women, men were biologically older and, in general, they had unhealthier life habits. The effect of sex on biological aging was partly mediated by body mass index and, in older twins, by smoking. Sex was directly associated with biological aging and the association was stronger in older twins. Previously reported sex differences in life span are also evident in biological aging. Declining smoking prevalence among men is a plausible explanation for the narrowing of the difference in life expectancy between the sexes. Data generated by the epigenetic clocks may help in estimating the effects of lifestyle and environmental factors on aging and in predicting aging in future generations.
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全基因组甲基化谱揭示了人类衰老速度的定量观点。
影响因子：
16
作者：
Hannum, Gregory;Guinney, Justin;Zhao, Ling;Zhang, Li;Hughes, Guy;Sadda, SriniVas;Klotzle, Brandy;Bibikova, Marina;Fan, Jian-Bing;Gao, Yuan;Deconde, Rob;Chen, Menzies;Rajapakse, Indika;Friend, Stephen;Ideker, Trey;Zhang, Kang
通讯作者：
Zhang, Kang
1950 年至 2014 年，吸烟对欧洲预期寿命性别差异的影响不断变化。
影响因子：
13.6
作者：
Janssen F
通讯作者：
Janssen F
影响因子：
4.6
作者：
Ruokolainen, Otto;Heloma, Antero;Puska, Pekka
通讯作者：
Puska, Pekka
DOI：
10.18632/aging.101414
发表时间：
2018-04-18
期刊：
Aging
影响因子：
--
作者：
Levine ME;Lu AT;Quach A;Chen BH;Assimes TL;Bandinelli S;Hou L;Baccarelli AA;Stewart JD;Li Y;Whitsel EA;Wilson JG;Reiner AP;Aviv A;Lohman K;Liu Y;Ferrucci L;Horvath S
通讯作者：
Horvath S
影响因子：
12.3
作者：
Horvath S
通讯作者：
Horvath S