Age-associated alteration in naive and memory Th17 cell response in humans.
Age-associated alteration in naive and memory Th17 cell response in humans.
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DOI：
10.1016/j.clim.2011.03.018
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发表时间：
2011-07
期刊：
影响因子：
--
通讯作者：
Kang I
中科院分区：
文献类型：
--
作者：
Lee JS;Lee WW;Kim SH;Kang Y;Lee N;Shin MS;Kang SW;Kang I
Th 17细胞产生在宿主防御中起重要作用的IL-17。然而，人们对衰老是否影响人类Th 17细胞知之甚少。在这里，我们证明了健康老年人（年龄≥65岁）与健康年轻人（年龄≤40岁）相比，记忆CD 4 + T细胞中IL-17产生细胞的频率降低，而两组在相同的记忆细胞亚群中具有相似的IFN-γ产生细胞的频率。相比之下，与健康年轻人相比，健康老年人从幼稚CD 4 + T细胞分化出的IL-17产生效应细胞增加，但IFN-γ产生细胞没有增加。ELISA的结果也显示了类似的发现，与年轻人相比，老年人中幼稚CD 4 + T细胞的IL-17产生增加，记忆CD 4 + T细胞的IL-17产生减少。这些发现表明，衰老对人类幼稚和记忆Th 17细胞反应的影响不同。
Th17 cells produce IL-17 that plays an important role in host defense. However, little is known about whether aging affects human Th17 cells. Here we demonstrated that healthy elderly people (age≥65) had a decreased frequency of IL-17-producing cells in memory CD4+ T cells compared to healthy young people (age≤40) while both groups had similar frequencies of IFN-γ-producing cells in the same memory cell subset as measured by flow cytometry. In contrast, the healthy elderly had increased differentiation of IL-17-producing effector cells but not IFN-γ-producing cells from naïve CD4+ T cells compared to the healthy young. The results of ELISA also showed similar findings with increased IL-17 production from naïve CD4+ T cells and decreased IL-17 production from memory CD4+ T cells in the elderly compared to the young. These findings indicate that aging differentially affects naïve and memory Th17 cell responses in humans.
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人白细胞介素17产生的细胞起源于CD161+ CD4+ T细胞前体。
影响因子：
15.3
作者：
Cosmi, Lorenzo;De Palma, Raffaele;Santarlasci, Veronica;Maggi, Laura;Capone, Manuela;Frosali, Francesca;Rodolico, Gabriella;Querci, Valentina;Abbate, Gianfranco;Angeli, Roberta;Berrino, Liberato;Fambrini, Massimiliano;Caproni, Marzia;Tonelli, Francesco;Lazzeri, Elena;Parronchi, Paola;Liotta, Francesco;Maggi, Enrico;Romagnani, Sergio;Annunziato, Francesco
通讯作者：
Annunziato, Francesco
影响因子：
64.5
作者：
Ivanov, Ivaylo I.;McKenzie, Brent S.;Littman, Dan R.
通讯作者：
Littman, Dan R.
影响因子：
11.8
作者：
Horn, David L.;Neofytos, Dionissios;Webster, Karen M.
通讯作者：
Webster, Karen M.
影响因子：
30.3
作者：
Stout-Delgado HW;Du W;Shirali AC;Booth CJ;Goldstein DR
通讯作者：
Goldstein DR
影响因子：
6.4
作者：
Huang, WT;Na, L;Schwarzenberger, P
通讯作者：
Schwarzenberger, P