Differential expression of IRF8 in subsets of macrophages and dendritic cells and effects of IRF8 deficiency on splenic B cell and macrophage compartments.
Differential expression of IRF8 in subsets of macrophages and dendritic cells and effects of IRF8 deficiency on splenic B cell and macrophage compartments.
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DOI：
10.1007/s12026-008-8032-2
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发表时间：
2009
影响因子：
4.4
通讯作者：
Morse, Herbert C., III
中科院分区：
文献类型：
--
作者：
Qi, Chen-Feng;Li, Zhaoyang;Raffeld, Mark;Wang, Hongsheng;Kovalchuk, Alexander L.;Morse, Herbert C., III
IRF 8是一种主要限于造血细胞的转录因子，已知其影响树突状细胞（DC）、巨噬细胞、粒细胞和B细胞的分化和功能。在人扁桃体中，IRF8由滤泡内巨噬细胞和DC以高水平表达，但由生发中心（GC）中的易染体巨噬细胞以低得多的水平表达，并且由滤泡DC表达很少（如果有的话）。IRF 8缺陷小鼠的脾脏中白色髓滤泡和形状不规则的GC数量减少。滤泡B细胞的频率显着减少，而边缘区（MZ）B细胞的数量增加。此外，MZ巨噬细胞数量减少且分布异常，而嗜金属巨噬细胞正常。这些发现证明了B细胞、DC和巨噬细胞的不同亚群对IRF 8的不同需求。
IRF8, a transcription factor restricted primarily to hematopoietic cells, is known to influence the differentiation and function of dendritic cells (DC), macrophages, granulocytes and B cells. In human tonsil, IRF8 is expressed at high levels by intrafollicular macrophages and DC, but at much lower levels by tingible body macrophages in germinal centers (GCs) and little, if at all, by follicular DC. Spleens of IRF8-defficient mice had reduced numbers of white pulp follicles and GCs that were irregular in shape. The frequency of follicular B cells was significantly reduced while the population of marginal zone (MZ) B cells was increased. In addition, MZ macrophages were reduced in number and abnormally distributed, while metallophilic macrophages were normal. These findings demonstrate differential requirements for IRF8 among distinct subsets of B cells, DC, and macrophages.
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影响因子：
56.9
作者：
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通讯作者：
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影响因子：
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