Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of brain glial cell activation in multiple sclerosis.
Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of brain glial cell activation in multiple sclerosis.
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DOI：
10.1177/1352458516681504
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发表时间：
2017-10
期刊：
影响因子：
--
通讯作者：
Matthews PM
中科院分区：
文献类型：
--
作者：
Datta G;Violante IR;Scott G;Zimmerman K;Santos-Ribeiro A;Rabiner EA;Gunn RN;Malik O;Ciccarelli O;Nicholas R;Matthews PM
多发性硬化（MS）的特征在于由小胶质细胞和星形胶质细胞介导的弥漫性炎症反应。脑转运蛋白（TSPO）正电子发射断层扫描（PET）和[肌醇]磁共振波谱（MRS）成像一起使用，以评估这一点。探索MS中MRS和PET [11 C] PBR 28与一系列脑炎症负荷之间的体内关系。共研究了23例患者。采用[11 C] PBR 28进行TSPO PET成像，进行单体素MRS和常规MRI序列。采用扩展残疾状态量表（EDSS）和多发性硬化功能综合评分（MSFC）评定残疾程度。[11 C] PBR 28摄取和[肌醇]不相关。当整个队列按较高的[11 C] PBR 28炎症负荷分层时，[肌醇]与[11 C] PBR 28摄取呈正相关（斯皮尔曼ρ = 0.685，p = 0.014）。[11 C] PBR 28摄取与MRS肌酸标准化N-乙酰天冬氨酸（NAA）浓度和灰质体积之间存在中度相关性。MSFC与灰质体积相关（ρ = 0.535，p = 0.009）。其他影像学或临床指标之间无相关性。MRS [肌醇]和PET [11 C] PBR 28测量独立的炎症过程，这些炎症过程可能更常见于更严重的炎症性疾病。通过[11 C] PBR 28摄取测量的小胶质细胞活化与神经元完整性丧失和灰质萎缩相关。
Multiple sclerosis (MS) is characterized by a diffuse inflammatory response mediated by microglia and astrocytes. Brain translocator protein (TSPO) positron-emission tomography (PET) and [myo-inositol] magnetic resonance spectroscopy (MRS) imaging was used together to assess this. To explore the in vivo relationships between MRS and PET [11C]PBR28 in MS with a range of brain inflammatory burdens. A total of 23 patients were studied. TSPO PET imaging with [11C]PBR28, single voxel MRS and conventional MRI sequences were undertaken. Disability was assessed by Expanded Disability Status Scale (EDSS) and Multiple Sclerosis Functional Composite (MSFC). [11C]PBR28 uptake and [myo-inositol] were not associated. When the whole cohort was stratified by higher [11C]PBR28 inflammatory burden, [myo-inositol] was positively correlated to [11C]PBR28 uptake (Spearman’s ρ = 0.685, p = 0.014). Moderate correlations were found between [11C]PBR28 uptake and both MRS creatine normalised N-acetyl aspartate (NAA) concentration and grey matter volume. MSFC was correlated with grey matter volume (ρ = 0.535, p = 0.009). There were no associations between other imaging or clinical measures. MRS [myo-inositol] and PET [11C]PBR28 measure independent inflammatory processes which may be more commonly found together with more severe inflammatory disease. Microglial activation measured by [11C]PBR28 uptake was associated with loss of neuronal integrity and grey matter atrophy.
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DOI：
10.1007/s00259-015-3149-8
发表时间：
2016-01-01
影响因子：
9.1
作者：
Collste, K.;Forsberg, A.;Cervenka, S.
通讯作者：
Cervenka, S.
影响因子：
14.5
作者：
Fu, L;Matthews, PM;Arnold, DL
通讯作者：
Arnold, DL
影响因子：
5.3
作者：
Murray, Melissa E.;Przybelski, Scott A.;Kantarci, Kejal
通讯作者：
Kantarci, Kejal
影响因子：
11.2
作者：
Polman CH;Reingold SC;Banwell B;Clanet M;Cohen JA;Filippi M;Fujihara K;Havrdova E;Hutchinson M;Kappos L;Lublin FD;Montalban X;O'Connor P;Sandberg-Wollheim M;Thompson AJ;Waubant E;Weinshenker B;Wolinsky JS
通讯作者：
Wolinsky JS
影响因子：
9.9
作者：
Politis, Marios;Giannetti, Paolo;Piccini, Paola
通讯作者：
Piccini, Paola