Simultaneous Time Interleaved MultiSlice (STIMS) for Rapid Susceptibility Weighted acquisition.
Simultaneous Time Interleaved MultiSlice (STIMS) for Rapid Susceptibility Weighted acquisition.
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DOI：
10.1016/j.neuroimage.2017.04.036
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发表时间：
2017-07-15
期刊：
影响因子：
5.7
通讯作者：
Setsompop K
中科院分区：
文献类型：
--
作者：
Bilgic B;Ye H;Wald LL;Setsompop K
T2* 加权3D梯度回波（GRE）采集是磁敏感加权成像（SWI）和定量磁敏感标测（QSM）的主要序列。这些应用需要长的回波时间（TE）来建立相位对比，需要长的重复时间（TR），并且导致过长的扫描。长TE采集在每个TR内产生大量未使用的时间，这些时间可用于多回波采样或使用回波偏移技术进行额外的图像编码。后者导致采集时间的显著节省，同时保持期望的相位和T2* 对比度。在这项工作中，我们介绍了同步时间交错多切片（STIMS）回波移位技术，它减轻了板边界文物交错梳状切片组与同步多切片（SMS）的激励。这享有与先前引入的多平板版本相同的3D信号平均的SNR益处，其中每个平板组利用kz相位编码进行子分辨。此外，我们将联合收割机SMS回波偏移与压缩感知（CS）波加速相结合，这增强了具有随机欠采样和稀疏先验的Wave-CAIPI采集/重建。因此，STIMS和CS-Wave组合产生了比传统全编码高45倍的加速，允许在3 T下以39 ms的长TE进行15秒的全脑采集，分辨率为1.5 mm各向同性。除了利用由于长TE而导致的空序列时间之外，STIMS是一种通用概念，其可以利用由于例如磁化准备的快速梯度回波（MPWE）和流体衰减反转恢复（FLAIR）序列中的反转模块而导致的间隙。
T2* weighted 3D Gradient Echo (GRE) acquisition is the main sequence used for Susceptibility Weighted Imaging (SWI) and Quantitative Susceptibility Mapping (QSM). These applications require a long echo time (TE) to build up phase contrast, requiring a long repetition time (TR), and leading to excessively lengthy scans. The long TE acquisition creates a significant amount of unused time within each TR, which can be utilized for either multi-echo sampling or additional image encoding with the echo-shift technique. The latter leads to significant saving in acquisition time while retaining the desired phase and T2* contrast. In this work, we introduce the Simultaneous Time Interleaved MultiSlice (STIMS) echo-shift technique, which mitigates slab boundary artifacts by interleaving comb-shaped slice groups with Simultaneous MultiSlice (SMS) excitation. This enjoys the same SNR benefit of 3D signal averaging as previously introduced multi-slab version, where each slab group is sub-resolved with kz phase encoding. Further, we combine SMS echo-shift with Compressed Sensing (CS) Wave acceleration, which enhances Wave-CAIPI acquisition/reconstruction with random undersampling and sparsity prior. STIMS and CS-Wave combination thus yields up to 45-fold acceleration over conventional full encoding, allowing a 15 sec full-brain acquisition with 1.5 mm isotropic resolution at long TE of 39 ms at 3T. In addition to utilizing empty sequence time due to long TE, STIMS is a general concept that could exploit gaps due to e.g. inversion modules in magnetization-prepared rapid gradient- echo (MPRAGE) and fluid attenuated inversion recovery (FLAIR) sequences.
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