In silico Interrogation of Insect Central Complex Suggests Computational Roles for the Ellipsoid Body in Spatial Navigation.
In silico Interrogation of Insect Central Complex Suggests Computational Roles for the Ellipsoid Body in Spatial Navigation.
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DOI：
10.3389/fnbeh.2017.00142
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发表时间：
2017
影响因子：
3
通讯作者：
Hirth F
中科院分区：
文献类型：
--
作者：
Fiore VG;Kottler B;Gu X;Hirth F
昆虫脑中的中枢复合体是由中线神经柱组成的复合体，参与处理感觉线索和介导行为输出以协调空间导航。尽管最近的进展，然而，感觉整合和运动动作选择的神经机制仍然在很大程度上难以捉摸。特别是，目前还不清楚中央复合体如何利用感觉输入来实现与空间导航相关的运动功能。在这里，我们报告了一个在硅审讯的中央复杂介导的空间导航，特别强调椭圆体。基于已知的连接和功能，我们开发了一个计算模型来测试中央复合体的局部连接体如何介导感觉运动整合以指导不同形式的行为输出。我们的模拟表明，集成的多个传感器源可以有效地执行在椭球体。这种处理过的信息被用来触发连续的动作选择序列，从而产生自运动、避障和不同复杂度的模拟环境的导航。对感知到的感官刺激的运动反应可以存储在中枢复合体的神经结构中，以模拟依赖于集体引导线索的导航，类似于感官驱动的先天或习惯性行为。通过比较不同输入信息源条件下的行为，我们展示了模拟昆虫计算视觉输入和身体姿态来估计其在空间中的位置。最后，我们测试了中央复合体的局部连接体是否也允许在不同的行动过程中回忆有意的行为序列所需的灵活性。我们的模拟表明，中央复合体可以编码运动和空间信息的组合表示，以追求一个目标，从而成功地指导定向行为。总之，观察到的计算功能确定中央复杂的电路，特别是椭圆体，作为一个关键的神经相关参与空间导航。
The central complex in the insect brain is a composite of midline neuropils involved in processing sensory cues and mediating behavioral outputs to orchestrate spatial navigation. Despite recent advances, however, the neural mechanisms underlying sensory integration and motor action selections have remained largely elusive. In particular, it is not yet understood how the central complex exploits sensory inputs to realize motor functions associated with spatial navigation. Here we report an in silico interrogation of central complex-mediated spatial navigation with a special emphasis on the ellipsoid body. Based on known connectivity and function, we developed a computational model to test how the local connectome of the central complex can mediate sensorimotor integration to guide different forms of behavioral outputs. Our simulations show integration of multiple sensory sources can be effectively performed in the ellipsoid body. This processed information is used to trigger continuous sequences of action selections resulting in self-motion, obstacle avoidance and the navigation of simulated environments of varying complexity. The motor responses to perceived sensory stimuli can be stored in the neural structure of the central complex to simulate navigation relying on a collective of guidance cues, akin to sensory-driven innate or habitual behaviors. By comparing behaviors under different conditions of accessible sources of input information, we show the simulated insect computes visual inputs and body posture to estimate its position in space. Finally, we tested whether the local connectome of the central complex might also allow the flexibility required to recall an intentional behavioral sequence, among different courses of actions. Our simulations suggest that the central complex can encode combined representations of motor and spatial information to pursue a goal and thus successfully guide orientation behavior. Together, the observed computational features identify central complex circuitry, and especially the ellipsoid body, as a key neural correlate involved in spatial navigation.
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