Pituicytoma with pleomorphism: A case report with cytological findings
Pituicytoma with pleomorphism: A case report with cytological findings
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多形性垂体细胞瘤：附细胞学检查结果的病例报告
DOI：
10.1002/dc.25045
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发表时间：
2022
影响因子：
1.3
通讯作者：
Nagashima Yoji
中科院分区：
文献类型：
--
作者：
Shimizu Ayako;Nonami Yuji;Kanamuro Toshiko;Masui Kenta;Yamamoto Tomoko;Amano Kosaku;Kawamata Takakazu;Ichihara Atsuhiro;Nagashima Yoji
垂体细胞瘤是一种罕见的肿瘤，发生于垂体后叶或垂体柄，其细胞学表现尚未得到很好的描述。我们经历了一例垂体细胞瘤，由于其细胞的多形性，术中很难诊断。在鞍部发现一个最大直径为18 mm的肿瘤，患者为40多岁的日本妇女。术中压榨细胞学和组织学检查均见多形性梭形或圆形细胞，包括多核细胞。肿瘤细胞TTF-1、S-100蛋白和波形蛋白阳性，胶质纤维酸性蛋白和上皮膜抗原部分阳性，突触素、垂体前叶激素、CD34、寡核苷酸、PAX8和Napsin阴性。Ki-67标记指数为2.0%。鉴别诊断的肿瘤一般包括垂体腺瘤、颅咽管瘤、生殖细胞瘤和转移性肿瘤，细胞学观点包括毛细胞性星形细胞瘤和脑膜瘤。然而，我们的病例仅从形态上很难与高级别胶质瘤相鉴别，包括TTF-1在内的免疫组织化学有助于鉴别。
Pituicytoma is a rare neoplasm, arising in the posterior pituitary or in the hypophyseal stalk, and its cytological findings have not yet been well‐described. We have experienced a case of pituicytoma, which was difficult to diagnose intraoperatively, because of its cellular pleomorphism. A tumor measuring 18 mm in maximum diameter was found at the sella turcica in a Japanese woman in her forties. Both intraoperative crush cytology and histology of the resected tumor showed pleomorphic spindle or round cells, including multinucleated cells. Tumor cells were positive for TTF‐1, S‐100 protein, and vimentin, partially positive for glial fibrillary acidic protein and epithelial membrane antigen, and negative for synaptophysin, hormones of the anterior pituitary gland, CD34, Olig2, PAX8, and napsin A. Ki‐67 labeling index was 2.0%. Tumors included in the differential diagnosis in general are pituitary adenoma, craniopharyngioma, germinoma, and metastatic tumor on the radiological standpoint, and pilocytic astrocytoma and meningioma on the cytological standpoint. However, our case was difficult to differentiate especially from high‐grade glioma only by morphology, and immunohistochemistry including TTF‐1 was helpful.
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DOI：
--
发表时间：
2013
期刊：
影响因子：
--
作者：
M. Wick;V. Livolsi;J. Pfeifer;E. Stelow;P. Wakely
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P. Wakely
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影响因子：
7.1
作者：
A. Viaene;Eddie B. Lee;J. Rosenbaum;Ilya M. Nasrallah;M. Nasrallah
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M. Nasrallah
影响因子：
2.3
作者：
Wang, Junmei;Liu, Zhaoxia;Li, Guilin
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类似垂体腺瘤的鞍内脑膜瘤1例[J].
DOI：
--
发表时间：
2001
期刊：
No shinkei geka. Neurological surgery
影响因子：
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作者：
S. Matsumoto;M. Hayase;H. Imamura;Y. Oda;H. Kikuchi;M. Katayama;T. Ishihara
通讯作者：
T. Ishihara
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影响因子：
1.3
作者：
N. Ghosal;Sumit Thakar;S. Kumaran;A. Hegde
通讯作者：
A. Hegde