The effect of TTX‐activity blockade and total darkness on the formation of retinotopy in the goldfish retinotectal projection

The effect of TTX‐activity blockade and total darkness on the formation of retinotopy in the goldfish retinotectal projection
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TTX活性阻断和完全黑暗对金鱼视网膜顶盖投影视网膜形成的影响

DOI:
10.1002/cne.903030307
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发表时间:
1991
影响因子:
2.5
通讯作者:
R. Meyer
R. Meyer
中科院分区:
医学3区
文献类型:
--
作者:
Michael D. Olson;R. Meyer

文献摘要

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在正常的金鱼中,相邻的视网膜神经节细胞终止于一个小的顶盖位点,以产生这种投射的精确视网膜病变特征。这可以通过用WGA-HRP的小“点”注射标记邻近的神经节细胞来直接证明,这在顶盖的视网膜定位适当的部分产生单个小斑块的产物。当视神经被压碎时,先前发现来自这些点注射的标记在再生的早期阶段广泛分散。随着时间的推移,标签随后浓缩,通常为几个离散的斑块,让人想起眼优势柱。
In the normal goldfish, neighboring retinal ganglion cells terminate in one small tectal locus to produce the precise retinotopy characteristic of this projection. This can be directly demonstrated by labeling neighboring ganglion cells with small “spot” injections of WGA‐HRP, which yield a single small patch of product at the retinotopically appropriate part of the tectum. When the optic nerve is crushed, label from these spot injections was previously found to be widely dispersed during the early phase of regeneration. With time, label subsequently condensed, typically into several discrete patches reminiscent of ocular dominance columns.
DOI: 10.1016/0165-3806(83)90067-6
发表时间: 1983
期刊: Brain research
影响因子: 2.9
作者:
Meyer,RL
通讯作者: Meyer,RL
在没有视神经支配的情况下,金鱼顶盖的局部相关活动。
DOI: 10.1016/0165-3806(88)90166-6
发表时间: 1988
期刊: Brain research
影响因子: 2.9
作者:
Meyer,RL;Brink,DL
通讯作者: Brink,DL
来自同基因双鼻蛙眼的眼睛优势柱。
DOI: 10.1126/science.6857287
发表时间: 1983
期刊: Science (New York, N.Y.)
影响因子: --
作者:
Ide,CF;Fraser,SE;Meyer,RL
通讯作者: Meyer,RL
通过光纤重新标记金鱼顶盖的测试。
DOI: 10.1016/0165-3806(87)90130-1
发表时间: 1987
期刊: Brain research
影响因子: 2.9
作者:
Meyer,RL
通讯作者: Meyer,RL