Negative aspects of close relationships as risk factors for cognitive aging.
Negative aspects of close relationships as risk factors for cognitive aging.
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DOI：
10.1093/aje/kwu236
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发表时间：
2014-12-01
影响因子：
5
通讯作者：
Brunner EJ
中科院分区：
文献类型：
--
作者：
Liao J;Head J;Kumari M;Stansfeld S;Kivimaki M;Singh-Manoux A;Brunner EJ
社会关系对认知老化的影响程度尚不清楚。在这项研究中，我们调查了中年生活质量的密切关系与随后的认知能力下降。白厅II研究的参与者（n = 5，873;首次认知评估时年龄为45-69岁）在10年内（1997-1999年至2007-2009年）进行了3次执行功能和记忆测试。中年消极和积极方面的亲密关系进行了评估，两次使用亲密的人问卷在8年前的认知评估。亲密关系的消极方面，而不是积极方面，与加速认知老化有关。在亲密关系的负面影响中，前三分之一的参与者在执行功能方面经历了比后三分之一的参与者更快的10年变化（-0.04标准差，95%置信区间：-0.08，-0.01），这与60岁的参与者在调整社会人口统计学和健康状况后的认知能力下降相比。纵向分析没有发现反向因果关系的证据。这项研究强调了区分社会关系方面的重要性，以评估其与认知老化的独特关联。
The extent to which social relationships influence cognitive aging is unclear. In this study, we investigated the association of midlife quality of close relationships with subsequent cognitive decline. Participants in the Whitehall II Study (n = 5,873; ages 45–69 years at first cognitive assessment) underwent executive function and memory tests 3 times over a period of 10 years (1997–1999 to 2007–2009). Midlife negative and positive aspects of close relationships were assessed twice using the Close Persons Questionnaire during the 8 years preceding cognitive assessment. Negative aspects of close relationships, but not positive aspects, were associated with accelerated cognitive aging. Participants in the top third of reported negative aspects of close relationships experienced a faster 10-year change in executive function (−0.04 standard deviation, 95% confidence interval: −0.08, −0.01) than those in the bottom third, which was comparable with 1 extra year of cognitive decline for participants aged 60 years after adjustment for sociodemographic and health status. Longitudinal analysis found no evidence of reverse causality. This study highlights the importance of differentiating aspects of social relationships to evaluate their unique associations with cognitive aging.
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