Molecular Changes Occurring During Reverse Remodelling Following Left Ventricular Assist Device Support
Molecular Changes Occurring During Reverse Remodelling Following Left Ventricular Assist Device Support
复制标题
左心室辅助装置支持后逆重塑过程中发生的分子变化
DOI：
--
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发表时间：
2010
影响因子：
3.4
通讯作者：
Robert S. George
中科院分区：
文献类型：
--
作者：
E. Birks;Robert S. George
重构是心力衰竭进展中发生的中心特征。然而，使用左心室辅助装置（LVAD）卸载心脏可导致许多重构变化逆转，即使是在晚期心力衰竭患者中。LVAD卸载还可以导致改善的心肌功能，并且这种改善可以足以允许移除设备，使患者过上正常的生活。我们回顾了分子变化，已被证明与左心室辅助装置卸载患者桥接移植，也发生在心肌功能恢复到足以有设备删除的患者的心肌。在这两个肌细胞和基质的变化进行审查。
Remodelling is the central feature that occurs in the progression of heart failure. However, unloading of the heart with a left ventricular assist device (LVAD) can lead to reversal of many of the remodelling changes even in patients with advanced heart failure. LVAD unloading can also lead to improved myocardial function and this improvement can be sufficient to allow removal of the device leaving the patient to lead a normal life. We review the molecular changes that have been demonstrated with LVAD unloading in patients bridged to transplantation and also those that have occurred in the myocardium of patients that have recovered their myocardial function enough to have the device removed. Changes in both the myocyte and the matrix are reviewed.
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影响因子：
20.1
作者：
OLIVETTI, G;CAPASSO, JM;ANVERSA, P
通讯作者：
ANVERSA, P
影响因子：
37.8
作者：
CONRAD, CH;BROOKS, WW;BING, OHL
通讯作者：
BING, OHL
DOI：
10.1016/s0022-2828(05)82390-9
发表时间：
1995-06-01
影响因子：
5
作者：
CLEUTJENS, JPM;KANDALA, JC;WEBER, KT
通讯作者：
WEBER, KT
DOI：
10.1073/pnas.97.23.12746
发表时间：
2000-11-07
影响因子：
11.1
作者：
Li, YY;Feng, YQ;Feldman, AM
通讯作者：
Feldman, AM
影响因子：
24
作者：
Klotz, S;Barbone, A;Burkhoff, D
通讯作者：
Burkhoff, D