Depression and diabetes: unhealthy bedfellows.
Depression and diabetes: unhealthy bedfellows.
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DOI：
10.1002/da.20683
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发表时间：
2010-04
影响因子：
7.4
通讯作者：
Katon, Wayne
中科院分区：
文献类型：
--
作者：
Katon, Wayne
抑郁症和糖尿病之间的联系已经被医生描述了几百年。托马斯威利斯，一位早期的英国医生和解剖学家，在17世纪中期写道，糖尿病是由“悲伤或长期悲伤和其他抑郁症”引起的。近年来，研究人员认为抑郁症和糖尿病之间存在双向联系（图1）。[1]早期的抑郁症已被证明与不良的健康行为有关，如缺乏体力活动，吸烟和肥胖。[2]抑郁症还与下丘脑-垂体-肾上腺轴（HPA）调节失调、皮质醇水平升高、向心性肥胖的发展、胰岛素敏感性缺乏、促炎症因子水平升高以及自主神经系统稳态的变化有关。[3，4]这些不良的健康行为和心理生理变化可能解释了最近一项系统综述的结果，该综述确定成年早期的抑郁症与糖尿病发展风险增加有关。[5]抑郁症也与糖尿病患者对自我护理方案的依从性差有关（即遵循饮食和运动方案，戒烟，并按处方服用药物）。[6]抑郁症的心理生理影响和缺乏自我护理方案的依从性可能会增加糖尿病并发症和死亡率的风险。与功能障碍相关的糖尿病并发症可能反过来促使抑郁发作。[七]《中国日报》
Associations between depression and diabetes have been described by physicians for several hundred years. Thomas Willis, an early English physician and anatomist, wrote during the mid-1600s that diabetes is caused by “sadness or long sorrow and other depressions.” In recent years, researchers have posited that there is a bidirectional link between depression and diabetes (Fig. 1).[1] Depression earlier in life has been shown to be associated with adverse health behaviors, such as lack of physical activity, smoking, and obesity.[2] Depression also has also been linked to hypothalamic-–pituitary–adrenal-axis (HPA) dysregulation, higher cortisol levels, development of centripetal obesity, lack of insulin sensitivity, higher levels of pro-inflammatory factors, and changes in autonomic nervous system homeostasis.[3, 4] These adverse health behaviors and psychophysiologic changes probably explain the findings from a recent systematic review, which determined that depression in early adult years is associated with an increased risk of development of diabetes.[5]Depression has also been linked with poor adherence to self-care regimens among patients with diabetes (ie following dietary and exercise regimens, quitting smoking, and taking medications as prescribed).[6] Both the psychophysiologic effects and the lack of adherence to self-care regimens associated with depression may increase the risk of diabetes complications and mortality. Diabetes complications that are associated with functional impairment may, in turn, precipitate a depressive episode.[7]
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影响因子：
--
作者：
Simon, Gregory E.;Katon, Wayne J.;Young, Bessie A.
通讯作者：
Young, Bessie A.
影响因子：
16.2
作者：
Katon, Wayne J.;Russo, Joan E.;Ciechanowski, Paul S.
通讯作者：
Ciechanowski, Paul S.
影响因子：
--
作者：
Danese, Andrea;Moffitt, Terrie E.;Harrington, HonaLee;Milne, Barry J.;Polanczyk, Guilherme;Pariante, Carmine M.;Poulton, Richie;Caspi, Avshalom
通讯作者：
Caspi, Avshalom
影响因子：
3.3
作者：
Katon, Wayne;Russo, Joan;Von Korff, Michael
通讯作者：
Von Korff, Michael
影响因子：
--
作者：
Wassertheil-Smoller, S;Shumaker, S;Dunbar-Jacob, J
通讯作者：
Dunbar-Jacob, J