Aquaporin-4 in Astroglial Cells in the CNS and Supporting Cells of Sensory Organs-A Comparative Perspective.
Aquaporin-4 in Astroglial Cells in the CNS and Supporting Cells of Sensory Organs-A Comparative Perspective.
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DOI：
10.3390/ijms17091411
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发表时间：
2016-08-26
影响因子：
5.6
通讯作者：
Mack AF
中科院分区：
文献类型：
--
作者：
Gleiser C;Wagner A;Fallier-Becker P;Wolburg H;Hirt B;Mack AF
水通道蛋白4（aquaporin-4，AQP 4）是脑内主要的水通道蛋白，是一种经典的水特异性水通道蛋白。它在基底外侧膜结构域的许多上皮组织中表达。在大多数感觉器官的支持细胞膜中，它以一种特殊的适应模式存在：在嗅粘膜的支持细胞中，AQP 4沿着基底外侧出现，在哺乳动物视网膜Müller细胞中，它是高度极化的。在内耳的耳蜗上皮中，它在一些细胞中基底外侧表达，但在另一些细胞中严格基底表达。在中枢神经系统内，水通道蛋白-4（AQP 4）由星形胶质细胞家族的细胞表达，更具体地，由星形胶质细胞和室管膜细胞表达。在哺乳动物脑中，AQP 4高密度地位于面向软脑膜表面和周围血管的星形胶质细胞终足的膜中。在这些位置，AQP 4在维持离子稳态和容量调节中起作用。这种高度极化的表达尚未在鱼的脑中观察到，其中星形胶质细胞具有长的突起并且主要作为放射状胶质细胞出现。在斑马鱼的脑中，发现沿着星形胶质细胞的放射状范围的AQP 4免疫反应。这表明AQP 4的极化表达并不存在于进化的所有阶段。因此，极化表达AQP 4作为一个稳定的离子环境和水平衡的控制机制的一部分发生在几个位置在支持和神经胶质细胞在进化过程中。AQP 4的这种最初的基底外侧膜定位在哺乳动物脑中的星形胶质细胞终足中转变为高度极化的表达，并作为神经血管单元的一部分有效地维持稳态。
The main water channel of the brain, aquaporin-4 (AQP4), is one of the classical water-specific aquaporins. It is expressed in many epithelial tissues in the basolateral membrane domain. It is present in the membranes of supporting cells in most sensory organs in a specifically adapted pattern: in the supporting cells of the olfactory mucosa, AQP4 occurs along the basolateral aspects, in mammalian retinal Müller cells it is highly polarized. In the cochlear epithelium of the inner ear, it is expressed basolaterally in some cells but strictly basally in others. Within the central nervous system, aquaporin-4 (AQP4) is expressed by cells of the astroglial family, more specifically, by astrocytes and ependymal cells. In the mammalian brain, AQP4 is located in high density in the membranes of astrocytic endfeet facing the pial surface and surrounding blood vessels. At these locations, AQP4 plays a role in the maintenance of ionic homeostasis and volume regulation. This highly polarized expression has not been observed in the brain of fish where astroglial cells have long processes and occur mostly as radial glial cells. In the brain of the zebrafish, AQP4 immunoreactivity is found along the radial extent of astroglial cells. This suggests that the polarized expression of AQP4 was not present at all stages of evolution. Thus, a polarized expression of AQP4 as part of a control mechanism for a stable ionic environment and water balanced occurred at several locations in supporting and glial cells during evolution. This initially basolateral membrane localization of AQP4 is shifted to highly polarized expression in astrocytic endfeet in the mammalian brain and serves as a part of the neurovascular unit to efficiently maintain homeostasis.
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影响因子：
4.5
作者：
Eckhard, A.;Dos Santos, A.;Loewenheim, H.
通讯作者：
Loewenheim, H.
影响因子：
3.6
作者：
Eckhard, Andreas;Gleiser, Corinna;Hirt, Bernhard
通讯作者：
Hirt, Bernhard
DOI：
10.1016/j.ijdevneu.2014.06.001
发表时间：
2014-08-01
影响因子：
1.8
作者：
Fallier-Becker, Petra;Vollmer, Joerg P.;Mack, Andreas F.
通讯作者：
Mack, Andreas F.
影响因子：
3.4
作者：
Delporte, Christine;Steinfeld, Serge
通讯作者：
Steinfeld, Serge
在小鼠海马中突触刺激期间，水通道蛋白4的缺失会增加细胞外K（+）浓度。
影响因子：
3.1
作者：
Haj-Yasein NN;Bugge CE;Jensen V;Østby I;Ottersen OP;Hvalby Ø;Nagelhus EA
通讯作者：
Nagelhus EA