Exosomal microRNA remodels the tumor microenvironment.
Exosomal microRNA remodels the tumor microenvironment.
复制标题
外泌体 microRNA 重塑肿瘤微环境
作者：
Jiang X;Hu S;Liu Q;Qian C;Liu Z;Luo D
肿瘤的发生、发展和转移依赖于肿瘤细胞与基质细胞之间的相互作用以及肿瘤微环境外的外在因素。外泌体微小RNA（Exosomal microRNA，miRNA）不仅参与肿瘤微环境内的通讯，还介导肿瘤微环境与外界环境之间的通讯。然而，大多数综述仅限于内源性外泌体miRNA在重塑肿瘤微环境中的作用。因此，我们在此综述内源性外泌体miRNA在肿瘤微环境中介导细胞间串扰，诱导转移前小生境形成的作用。为了将我们的视野置于微环境之外，我们还首次总结了有关来自牛奶，植物和微生物的外源性miRNA如何影响肿瘤微环境的最新研究。此外，为提高exosomal miRNA在肿瘤研究和临床应用中的价值，我们还基于exosomal miRNA在重塑肿瘤微环境中的综合作用，为今后的研究提供了一些新的思路。
Tumor occurrence, progression and metastasis depend on the crosstalk between tumor cells and stromal cells and on extrinsic factors outside the tumor microenvironment. Exosomal microRNA (miRNA) not only is involved in communications within the tumor microenvironment but also mediates communications between the extrinsic environment and tumor microenvironment. However, most reviews have been limited to the role of endogenous exosomal miRNA in remodeling the tumor microenvironment. Hence, we herein review the role of endogenous exosomal miRNA in mediating intercellular crosstalk within the tumor microenvironment, inducing the formation of the premetastatic niche. To place our vision outside the microenvironment, we also summarize for the first time the most recent studies regarding how exogenous miRNA derived from milk, plants and microbes influences the tumor microenvironment. Furthermore, to improve the value of exosomal miRNA in cancer research and clinical applications, we also provide some novel ideas for future research based on the comprehensive role of exosomal miRNA in remodeling the tumor microenvironment.
登录
查看更多内容
DOI：
10.1073/pnas.1209414109
发表时间：
2012-07-31
影响因子：
11.1
作者：
Fabbri, Muller;Paone, Alessio;Croce, Carlo M.
通讯作者：
Croce, Carlo M.
影响因子：
11.2
作者：
Grange, Cristina;Tapparo, Marta;Camussi, Giovanni
通讯作者：
Camussi, Giovanni
影响因子：
37.3
作者：
Armstrong DA;Green BB;Seigne JD;Schned AR;Marsit CJ
通讯作者：
Marsit CJ
影响因子：
8.8
作者：
Bryant, R. J.;Pawlowski, T.;Catto, J. W. F.;Marsden, G.;Vessella, R. L.;Rhees, B.;Kuslich, C.;Visakorpi, T.;Hamdy, F. C.
通讯作者：
Hamdy, F. C.
DOI：
10.1073/pnas.1019055108
发表时间：
2011-03-22
影响因子：
11.1
作者：
Arroyo, Jason D.;Chevillet, John R.;Tewari, Muneesh
通讯作者：
Tewari, Muneesh