Host-derived nitrate boosts growth of E. coli in the inflamed gut.
Host-derived nitrate boosts growth of E. coli in the inflamed gut.
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DOI：
10.1126/science.1232467
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发表时间：
2013-02-08
期刊：
影响因子：
--
通讯作者：
Bäumler AJ
中科院分区：
文献类型：
--
作者：
Winter SE;Winter MG;Xavier MN;Thiennimitr P;Poon V;Keestra AM;Laughlin RC;Gomez G;Wu J;Lawhon SD;Popova IE;Parikh SJ;Adams LG;Tsolis RM;Stewart VJ;Bäumler AJ
Changes in the microbial community structure are observed in individuals with intestinal inflammatory disorders. These changes are often characterized by a depletion of obligate anaerobic bacteria, whereas the relative abundance of facultative anaerobic Enterobacteriaceae increases. The mechanisms by which the host response shapes the microbial community structure, however, remain unknown. We show that nitrate generated as a by-product of the inflammatory response conferred a growth advantage to the commensal bacterium Escherichia coli in the large intestine of mice. Mice deficient for inducible nitric oxide synthase (iNOS) did not support growth of E. coli by nitrate respiration, suggesting that nitrate generated during inflammation was host-derived. Thus the inflammatory host response selectively enhances growth of commensal Enterobacteriaceae by generating electron acceptors for anaerobic respiration.
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影响因子：
6.7
作者：
Hoffman LR;Richardson AR;Houston LS;Kulasekara HD;Martens-Habbena W;Klausen M;Burns JL;Stahl DA;Hassett DJ;Fang FC;Miller SI
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DOI：
10.1073/pnas.0504978102
发表时间：
2005-08-02
影响因子：
11.1
作者：
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影响因子：
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作者：
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通讯作者：
Richardson, David E.