Telomeres and replicative cellular aging of the human placenta and chorioamniotic membranes.
Telomeres and replicative cellular aging of the human placenta and chorioamniotic membranes.
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DOI：
10.1038/s41598-021-84728-2
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发表时间：
2021-03-04
影响因子：
4.6
通讯作者：
Aviv A
中科院分区：
文献类型：
--
作者：
Lai TP;Simpson M;Patel K;Verhulst S;Noh J;Roche N;Heller D;Guirguis G;Shay JW;Herbig U;Aviv A
最近的假设提出，人类胎盘和绒毛膜羊膜（CAMs）经历端粒长度（TL）介导的衰老。这些假设是基于平均端粒长度（mTL）的测量，但复制性衰老是由短而功能失调的端粒引发的，而不是mTL。我们通过先锋方法，端粒最短长度测定，端粒功能障碍诱导的DNA损伤灶（TIF）在胎盘和CAMs妊娠18周和足月。从18周到足月，胎盘和CAMs都显示了短端粒和TIFs的积累，但mTL没有缩短。在胎盘中，TIFs与短端粒相关，但与mTL无关。羊膜内感染的早产妊娠CAMs显示mTL较短，短端粒比例增加。我们的结论是，胎盘和CAMs可能经历了tl介导的复制衰老。tl介导的复制老化是否在所有早产中起作用有待进一步研究。
Recent hypotheses propose that the human placenta and chorioamniotic membranes (CAMs) experience telomere length (TL)-mediated senescence. These hypotheses are based on mean TL (mTL) measurements, but replicative senescence is triggered by short and dysfunctional telomeres, not mTL. We measured short telomeres by a vanguard method, the Telomere shortest length assay, and telomere-dysfunction-induced DNA damage foci (TIF) in placentas and CAMs between 18-week gestation and at full-term. Both the placenta and CAMs showed a buildup of short telomeres and TIFs, but not shortening of mTL from 18-weeks to full-term. In the placenta, TIFs correlated with short telomeres but not mTL. CAMs of preterm birth pregnancies with intra-amniotic infection showed shorter mTL and increased proportions of short telomeres. We conclude that the placenta and probably the CAMs undergo TL-mediated replicative aging. Further research is warranted whether TL-mediated replicative aging plays a role in all preterm births.
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DOI：
10.3109/14767058.2014.961009
发表时间：
2015-09
期刊：
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
影响因子：
--
作者：
Kim SM;Romero R;Park JW;Oh KJ;Jun JK;Yoon BH
通讯作者：
Yoon BH
影响因子：
16.6
作者：
Lai TP;Zhang N;Noh J;Mender I;Tedone E;Huang E;Wright WE;Danuser G;Shay JW
通讯作者：
Shay JW
影响因子：
9.8
作者：
Conde-Agudelo A;Romero R
通讯作者：
Romero R
影响因子：
9.8
作者：
Jones CW;Gambala C;Esteves KC;Wallace M;Schlesinger R;O'Quinn M;Kidd L;Theall KP;Drury SS
通讯作者：
Drury SS
影响因子：
3.6
作者：
Phillippe, Mark;Phillippe, Shiela M.
通讯作者：
Phillippe, Shiela M.