Recombination resulting in virulence shift in avian influenza outbreak, Chile.
Recombination resulting in virulence shift in avian influenza outbreak, Chile.
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DOI：
10.3201/eid1004.030396
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发表时间：
2004-04
影响因子：
11.8
通讯作者：
Alexander DJ
中科院分区：
文献类型：
--
作者：
Suarez DL;Senne DA;Banks J;Brown IH;Essen SC;Lee CW;Manvell RJ;Mathieu-Benson C;Moreno V;Pedersen JC;Panigrahy B;Rojas H;Spackman E;Alexander DJ
甲型流感病毒在世界范围内发生在野鸟中，偶尔与商业鸡和火鸡中的暴发有关。然而，尚未从南美洲的野鸟或家禽中分离出禽流感病毒。最近在智利发生了H7N3低致病性禽流感（LPAI）鸡群暴发。一个月后，在死亡人数突然增加后，H7N3高致病性禽流感病毒被分离出来。LPAI病毒和HPAI病毒的所有8个基因的序列分析显示，除了在血凝素（HA）切割位点，病毒之间的微小差异。LPAI病毒具有与其他低致病性H7病毒相似的切割位点，但HPAI分离株具有30个核苷酸的插入物。插入可能是通过LPAI病毒的HA和核蛋白基因之间的重组发生的，导致毒力转移。所有八个基因片段的序列比较显示，智利病毒也不同于所有其他禽流感病毒，代表了一个独特的南美分支。
Influenza A viruses occur worldwide in wild birds and are occasionally associated with outbreaks in commercial chickens and turkeys. However, avian influenza viruses have not been isolated from wild birds or poultry in South America. A recent outbreak in chickens of H7N3 low pathogenic avian influenza (LPAI) occurred in Chile. One month later, after a sudden increase in deaths, H7N3 highly pathogenic avian influenza (HPAI) virus was isolated. Sequence analysis of all eight genes of the LPAI virus and the HPAI viruses showed minor differences between the viruses except at the hemagglutinin (HA) cleavage site. The LPAI virus had a cleavage site similar to other low pathogenic H7 viruses, but the HPAI isolates had a 30 nucleotide insert. The insertion likely occurred by recombination between the HA and nucleoprotein genes of the LPAI virus, resulting in a virulence shift. Sequence comparison of all eight gene segments showed the Chilean viruses were also distinct from all other avian influenza viruses and represent a distinct South American clade.
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影响因子：
3.8
作者：
Garcia, M;Crawford, JM;Perdue, ML
通讯作者：
Perdue, ML
影响因子：
10.7
作者：
Strimmer, K;vonHaeseler, A
通讯作者：
vonHaeseler, A
影响因子：
2.8
作者：
ALEXANDER, DJ;SPACKMAN, D
通讯作者：
SPACKMAN, D
DOI：
10.1590/s0102-09352001000300005
发表时间：
2001-06-01
影响因子：
0.4
作者：
Oliveira, JG;Belluci, MSP;Loureiro, BO
通讯作者：
Loureiro, BO
影响因子：
3.8
作者：
WALKER, JA;KAWAOKA, Y
通讯作者：
KAWAOKA, Y