In Vivo Genetic Strategies for the Specific Lineage Tracing of Stem Cells.
In Vivo Genetic Strategies for the Specific Lineage Tracing of Stem Cells.
复制标题
用于干细胞特定谱系追踪的体内遗传策略。
DOI：
10.2174/1574888x13666180726110138
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Wang Yazhou
中科院分区：
文献类型：
--
作者：
Fan Hong;Liu Xinyu;Shen Yahui;Chen Siwei;Huan Yu;Shan Junjia;Zhou Chengji;Wu Shengxi;Zhang Zifeng;Wang Yazhou
干细胞命运变化的表征对于理解某些干细胞在发育过程中和在疾病如癌症中的作用是必不可少的。在过去的二十年里，体内谱系示踪的研究越来越受到重视，因为它可以真实地揭示干细胞的分化、迁移甚至增殖。然而，直到最近才开发出特定的遗传工具。目的综述特异性谱系追踪的遗传工具的研究进展，重点介绍其在干细胞生态位信号研究中的应用。结果根据技术的发展，综述了三种主要的遗传策略，并对每种方法的优缺点进行了详细的分析。结论综合应用多种遗传学工具可以实现干细胞的体内特异性谱系追踪。
BACKGROUND Characterization of the fate changes of stem cells is essential to understand the roles of certain stem cells both during development and in diseases, such as cancer. In the past two decades, more and more importance has been paid to the studies of in vivo lineage tracing, because they could authentically reveal the differentiation, migration and even proliferation of stem cells. However, specific genetic tools have only been developed until recently. OBJECTIVE To summarize the progresses of genetic tools for specific lineage tracing with emphasis on their applications in investigating the stem cell niche signals. RESULTS Three major genetic strategies have been reviewed according to the development of technique, particularly the advantages and disadvantages of individual methods. CONCLUSION In vivo specific lineage tracing of stem cells could be achieved by comprehensive application of multiple genetic tools.
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影响因子：
--
作者：
T. Weissman;J. Sanes;J. Lichtman;J. Livet
通讯作者：
T. Weissman;J. Sanes;J. Lichtman;J. Livet
影响因子：
5.4
作者：
Trichas, Georgios;Begbie, Jo;Srinivas, Shankar
通讯作者：
Srinivas, Shankar
影响因子：
3.7
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Kim JH;Lee SR;Li LH;Park HJ;Park JH;Lee KY;Kim MK;Shin BA;Choi SY
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Choi SY
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64.5
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Hsu YC;Pasolli HA;Fuchs E
通讯作者：
Fuchs E
影响因子：
56.9
作者：
Venken, Koen J. T.;He, Yuchun;Bellen, Hugo J.
通讯作者：
Bellen, Hugo J.