A randomised cross-over pharmacokinetic bioavailability study of synthetic versus kiwifruit-derived vitamin C.
A randomised cross-over pharmacokinetic bioavailability study of synthetic versus kiwifruit-derived vitamin C.
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DOI：
10.3390/nu5114451
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发表时间：
2013-11-11
期刊：
影响因子：
5.9
通讯作者：
Vissers MC
中科院分区：
文献类型：
--
作者：
Carr AC;Bozonet SM;Vissers MC
猕猴桃是维生素C的丰富来源，还含有许多植物化学物质，如类黄酮，这可能会影响猕猴桃衍生维生素C的生物利用度。本研究的目的是使用随机交叉药代动力学研究设计比较合成与猕猴桃衍生维生素C的相对生物利用度。9名非吸烟男性（年龄18-35岁）接受咀嚼片（200 mg维生素C）或金猕猴桃（猕猴桃变种）的等效剂量。Sungold）。在干预后的8小时内，每半小时至每小时收集空腹血液和尿液。采用高效液相色谱电化学检测法测定血浆和尿液中的抗坏血酸含量。血浆抗坏血酸水平从干预后0.5小时开始升高（P = 0.008）。两种干预措施之间的血浆时间-浓度曲线无显著差异（P = 0.645）。对血浆抗坏血酸盐总增加的估计表明摄入的维生素C片剂和猕猴桃衍生的维生素C的完全吸收。从干预后两小时起，相对于尿肌酸酐，尿抗坏血酸排泄量增加（P < 0.001）。两种干预措施之间也存在显著差异，猕猴桃组中观察到抗坏血酸排泄增强（P = 0.016）。尿液排泄量分别计算为维生素C片剂和猕猴桃组摄入剂量的~40%和~50%。总的来说，我们的药代动力学研究表明猕猴桃衍生维生素C和合成维生素C的相对生物利用度相当。
Kiwifruit are a rich source of vitamin C and also contain numerous phytochemicals, such as flavonoids, which may influence the bioavailability of kiwifruit-derived vitamin C. The aim of this study was to compare the relative bioavailability of synthetic versus kiwifruit-derived vitamin C using a randomised cross-over pharmacokinetic study design. Nine non-smoking males (aged 18–35 years) received either a chewable tablet (200 mg vitamin C) or the equivalent dose from gold kiwifruit (Actinidia chinensis var. Sungold). Fasting blood and urine were collected half hourly to hourly over the eight hours following intervention. The ascorbate content of the plasma and urine was determined using HPLC with electrochemical detection. Plasma ascorbate levels increased from 0.5 h after the intervention (P = 0.008). No significant differences in the plasma time-concentration curves were observed between the two interventions (P = 0.645). An estimate of the total increase in plasma ascorbate indicated complete uptake of the ingested vitamin C tablet and kiwifruit-derived vitamin C. There was an increase in urinary ascorbate excretion, relative to urinary creatinine, from two hours post intervention (P < 0.001). There was also a significant difference between the two interventions, with enhanced ascorbate excretion observed in the kiwifruit group (P = 0.016). Urinary excretion was calculated as ~40% and ~50% of the ingested dose from the vitamin C tablet and kiwifruit arms, respectively. Overall, our pharmacokinetic study has shown comparable relative bioavailability of kiwifruit-derived vitamin C and synthetic vitamin C.
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影响因子：
5.9
作者：
Carr AC;Bozonet SM;Pullar JM;Simcock JW;Vissers MC
通讯作者：
Vissers MC
影响因子：
2.5
作者：
Carr, Anitra C;Pullar, Juliet M;Moran, Stephanie;Vissers, Margreet C M
通讯作者：
Vissers, Margreet C M
影响因子：
6.1
作者：
Ivanov, V;Carr, AC;Frei, B
通讯作者：
Frei, B
影响因子：
4.8
作者：
Song, J;Kwon, O;Levine, M
通讯作者：
Levine, M
影响因子：
3.9
作者：
Carter, Brett;Monsivais, Pablo;Drewnowski, Adam
通讯作者：
Drewnowski, Adam