Gating multiple signals through detailed balance of excitation and inhibition in spiking networks.
Gating multiple signals through detailed balance of excitation and inhibition in spiking networks.
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DOI：
10.1038/nn.2276
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发表时间：
2009-04
影响因子：
25
通讯作者：
Abbott, L. F.
中科院分区：
文献类型：
--
作者：
Vogels, Tim P.;Abbott, L. F.
最近的理论工作已经提供了信号在尖峰神经元网络中的传播的基本理解，但对这些信号的门控和控制机制尚未进行研究。在这里，我们介绍了一种在皮层网络中对多个信号进行门控的想法，该想法结合了信号传播原理和平衡网络的各个方面。具体来说，我们研究的网络中，传入的兴奋信号通常被局部诱发的抑制所取消，使目标层无反应。传输可以通过调节兴奋性和抑制性增益来打破这种详细的平衡。我们通过综合-放电神经元的大型网络中的详细平衡来说明门控。我们展示了多个信号的成功门控和研究失败模式，这些模式产生的影响让人想起临床观察到的病理。如果单个信号是可检测的，则详细平衡具有对多个信号进行门控的巨大能力。
Recent theoretical work has provided a basic understanding of signal propagation in networks of spiking neurons, but mechanisms for gating and controlling these signals have not been investigated previously. Here we introduce an idea for the gating of multiple signals in cortical networks that combines principles of signal propagation with aspects of balanced networks. Specifically, we study networks in which incoming excitatory signals are normally cancelled by locally evoked inhibition, leaving the targeted layer unresponsive. Transmission can be gated on by modulating excitatory and inhibitory gains to upset this detailed balance. We illustrate gating through detailed balance in large networks of integrate-and-fire neurons. We show successful gating of multiple signals and study failure modes that produce effects reminiscent of clinically observed pathologies. Provided that the individual signals are detectable, detailed balance has an enormous capacity for gating multiple signals.
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影响因子：
16.2
作者：
Mitchell, Jude F.;Sundberg, Kristy A.;Reynolds, John H.
通讯作者：
Reynolds, John H.
DOI：
10.1073/pnas.0308455101
发表时间：
2004-06-01
影响因子：
11.1
作者：
Jackson, ME;Homayoun, H;Moghaddam, B
通讯作者：
Moghaddam, B
影响因子：
16.2
作者：
Baca, Serapio M.;Marin-Burgin, Antonia;Kristan, William B., Jr.
通讯作者：
Kristan, William B., Jr.
影响因子：
2.5
作者：
Disney, Anita A.;Domakonda, Kunal V.;Aoki, Chiye
通讯作者：
Aoki, Chiye
影响因子：
--
作者：
Brunel, N
通讯作者：
Brunel, N