Antibody Dynamics and Durability in Coronavirus Disease-19.

Antibody Dynamics and Durability in Coronavirus Disease-19.
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DOI:
10.1016/j.cll.2021.10.004
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发表时间:
2022-03
影响因子:
1.7
通讯作者:
Wesemann DR
Wesemann DR
中科院分区:
医学4区
文献类型:
--
作者:
Zuiani A;Wesemann DR

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严重急性呼吸系统综合征冠状病毒2型(COVID-19)已成为几代人以来最大的全球健康威胁。研究人员空前动员,在SARS-CoV-2大流行开始的一年内,就产生了大量关于SARS-CoV-2体液反应的数据。对COVID-19中急性期抗体诱导和中期抗体持久性的快速发展的理解在个人层面上对告知患者护理和人群层面上对帮助预测传播动态非常重要。在这篇简短的综述中,我们将描述对免疫和感染的抗体反应的发展和维持,以及对COVID-19观察到的特异性抗体动力学。体液反应的这些关键特征对使用针对病毒的抗体疗法具有意义,并且可以告知个体被病毒再感染的可能性。
Severe acute respiratory syndrome coronavirus 2 (COVID)-19 has emerged as the greatest global health threat in generations. An unprecedented mobilization of researchers has generated a wealth of data on humoral responses to SARS-CoV-2 within a year of the pandemic’s beginning. The rapidly developed understanding of acute-phase antibody induction and medium-term antibody durability in COVID-19 is important at an individual level to inform patient care and a population level to help predict transmission dynamics. In this brief review, we will describe the development and maintenance of antibody responses to immunization and infections generally and the specific antibody dynamics observed for COVID-19. These crucial features of the humoral response have implications for the use of antibody therapeutics against the virus and can inform the likelihood of reinfection of individuals by the virus.
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发表时间: 2021-01-21
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